PREVALENCE OF GLUCOSE METABOLISM DISORDER AMONG OVER 10 YEARS OLD THALASSEMIC PATIENTS, HAJAR HOSPITAL OF SHAHREKORD, 2003

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RAEISI N.; MIRHOSSENI M.

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Title

PREVALENCE OF GLUCOSE METABOLISM DISORDER AMONG OVER 10 YEARS OLD THALASSEMIC PATIENTS, HAJAR HOSPITAL OF SHAHREKORD, 2003

Author(s)

RAEISI N. | MIRHOSSENI M. | Issue Writer Certificate

Keywords

GLUCOSE METABOLISMQ4

IRON OVERLOAD DISORDERSQ4

THALASSEMIA MAJORQ3

Abstract

Background and aim: Hyper transfusion therapy has increased the duration and quality of life in the patients with THALASSEMIA MAJOR. However it could lead to chronic iron overload and viral hepatitis that induce complications such as GLUCOSE METABOLISM disorders. The aim of this study was to find the prevalence of GLUCOSE METABOLISM disorders among β-thalassemic patients and compare with matched normal control group. Methods: The case group consisted of 40 multitransfused thalassemic patients (10-20 years old, F/M=47.5%, 52.5%) and the control group consisted of 40 matched normal persons. OGTT (Oral Glucose tolerance Test: blood sugar response to oral load of 1.75 g/ kg glucose) was performed in all persons. We also determined desferal dosage, serum ferritin level and markers of viral hepatitis (including HbsAg-HCV Ab-SGOT, SGPT, ALK.P) in thalassemic patients. Results: The prevalence of GLUCOSE METABOLISM disorders was higher in the thalassemic patients compared to the normal group (15% versus 0%, P=0.01). GLUCOSE METABOLISM disorders was not higher in patients with thalassemia and viral hepatitis than thalassemic patients without hepatitis (16.6% versus 8.8%, P>0.05). The high frequency of GLUCOSE METABOLISM disorders in thalassemic patients was related to serum ferritin level (P<0.05).Conclusion: Our data showed the role of iron overload in GLUCOSE METABOLISM disorders and requirement of periodic control of serum ferritin level in β-thalassemia major patients.

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APA: Copy

RAEISI, N., & MIRHOSSENI, M.. (2005). PREVALENCE OF GLUCOSE METABOLISM DISORDER AMONG OVER 10 YEARS OLD THALASSEMIC PATIENTS, HAJAR HOSPITAL OF SHAHREKORD, 2003 . JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 6(4), 51-55. SID. https://sid.ir/paper/58807/en

Vancouver: Copy

RAEISI N., MIRHOSSENI M.. PREVALENCE OF GLUCOSE METABOLISM DISORDER AMONG OVER 10 YEARS OLD THALASSEMIC PATIENTS, HAJAR HOSPITAL OF SHAHREKORD, 2003 . JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;6(4):51-55. Available from: https://sid.ir/paper/58807/en

IEEE: Copy

N. RAEISI, and M. MIRHOSSENI, “PREVALENCE OF GLUCOSE METABOLISM DISORDER AMONG OVER 10 YEARS OLD THALASSEMIC PATIENTS, HAJAR HOSPITAL OF SHAHREKORD, 2003 ,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 6, no. 4, pp. 51–55, 2005, [Online]. Available: https://sid.ir/paper/58807/en

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