Detection and Localization of HCA2 Receptors in Urinary System of Male Rats with Immunohistochemical Method

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HAMEDI S.; SHOMALI T.; Memarian Mojarrab m.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2018 | Volume:20 | Issue:3 Page(s): 43-49

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Information Journal Paper

Title

Detection and Localization of HCA2 Receptors in Urinary System of Male Rats with Immunohistochemical Method

Author(s)

HAMEDI S. | SHOMALI T. | Memarian Mojarrab m. | Issue Writer Certificate

Keywords

HCA2 receptorsQ1

immunohistochemistryQ2

urinary systemQ2

ratQ2

Abstract

Background and aims: HCA2 receptors have attracted much interest due to their role as the target of important hypolipidemic agent, niacin. In this study, the presence of HCA2 receptors as well as cell types that express them has been evaluated in different parts of male rats' urinary system including kidney, ureter, urinary bladder and urethra (in penis). Methods: In this experimental study, six adult male Wistar rats were used. Histological slides were made from above mentioned parts and were evaluated by immunohistochemical method. Results: In kidney, capillary epithelium showed a high reactivity while proximal epithelial cells were stained moderately. The epithelial cells of loop of Henle, distal and collective tubules as well as glomerular cells showed weak staining. In urinary bladder, transitional epithelium and capillary endothelium showed weak staining, while smooth muscle had no reactivity. In penile tissue, urethral epithelium and smooth muscle cells were weakly positive while capillary endothelial cells showed moderate reactivity. Conclusion: This study shows that HCA2 receptors are present in different parts of male rats' urinary tract. Distribution of these receptors is dependent to cell type and location in the urinary tract. The findings pave the road for future studies on possible role of these receptors in urinary system.

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APA: Copy

HAMEDI, S., SHOMALI, T., & Memarian Mojarrab, m.. (2018). Detection and Localization of HCA2 Receptors in Urinary System of Male Rats with Immunohistochemical Method. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 20(3 ), 43-49. SID. https://sid.ir/paper/58856/en

Vancouver: Copy

HAMEDI S., SHOMALI T., Memarian Mojarrab m.. Detection and Localization of HCA2 Receptors in Urinary System of Male Rats with Immunohistochemical Method. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;20(3 ):43-49. Available from: https://sid.ir/paper/58856/en

IEEE: Copy

S. HAMEDI, T. SHOMALI, and m. Memarian Mojarrab, “Detection and Localization of HCA2 Receptors in Urinary System of Male Rats with Immunohistochemical Method,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 3 , pp. 43–49, 2018, [Online]. Available: https://sid.ir/paper/58856/en

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