CENTRAL EFFECTS OF BACLOFEN, VIGABATRIN AND MIDAZOLAM ON SACCADIC EYE MOVEMENTS IN MAN.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2000 | Volume:2 | Issue:1 Page(s): 1-10

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Title

CENTRAL EFFECTS OF BACLOFEN, VIGABATRIN AND MIDAZOLAM ON SACCADIC EYE MOVEMENTS IN MAN.

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Keywords

SACCADIC EYE MOVEMENTSQ4

VIGABATRINQ4

BACLOFENQ4

MIDAZOLAMQ3

BENZODIAZEPINEQ4

Abstract

The novel technique of measuring SACCADIC EYE MOVEMENTS provides a sensitive means of assessing drug effects on this physiological action that is independent of conscious control. Although the physiology and anatomy of controlling SACCADIC EYE MOVEMENTS are well established. their pharmacology has only been partially investigated. Most of the works, using receptor selective drugs, investigated the effects of BENZODIAZEPINEs, which slows down SACCADIC EYE MOVEMENTS. The purpose of the present study was to further investigate the involvement of GABA-benzodiazepine receptor complex on initiation and control of various saccade parameters, using. the GABAb agonist BACLOFEN and the GABA transaminase inhibitor VIGABATRIN alone and in combination with the benzoaiazepine agonist MIDAZOLAM. This was carried out in nine young healthy volunteers using a double blind randomized, within-subjects" crossover, placebo controlled study design. Changes in psychological self-ratings of anxiety, sedation, alertness, and cardiovascular parameters were also measured. BACLOFEN and VIGABATRIN had no significant effect on saccade parameters, nor did they significantly change subjective self-ratings of sedation, anxiety or alertness. MIDAZOLAM on the other hand significantly altered various saccade parameters including peak saccade velocity, peak saccade acceleration, acceleration/deceleration ratio and saccade error. MIDAZOLAM also increased the sedation level and reduced the rating of anxiety and alertness. No interaction of either BACLOFEN or VIGABATRIN with MIDAZOLAM was observed. This study shows that SACCADIC EYE MOVEMENTS are not affected by increasing central nervous system GABA level, or by agonists acting at non-benzodiazepine-linked GABAb receptors, but are altered by BENZODIAZEPINE agonists. The fact that an effect was seen after administration of MIDAZOLAM but not after VIGABATRIN is puzzling, although a number of pharmacokinetic or other factors may be important. VIGABATRIN appeared to be unsuitable as a tool for investigating the effects of GABA on SACCADIC EYE MOVEMENTS and further studies using more selective GABAa agonists are needed.

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APA: Copy

. (2000). CENTRAL EFFECTS OF BACLOFEN, VIGABATRIN AND MIDAZOLAM ON SACCADIC EYE MOVEMENTS IN MAN.. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 2(1), 1-10. SID. https://sid.ir/paper/58864/en

Vancouver: Copy

. CENTRAL EFFECTS OF BACLOFEN, VIGABATRIN AND MIDAZOLAM ON SACCADIC EYE MOVEMENTS IN MAN.. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2000;2(1):1-10. Available from: https://sid.ir/paper/58864/en

IEEE: Copy

, “CENTRAL EFFECTS OF BACLOFEN, VIGABATRIN AND MIDAZOLAM ON SACCADIC EYE MOVEMENTS IN MAN.,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 2, no. 1, pp. 1–10, 2000, [Online]. Available: https://sid.ir/paper/58864/en

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