TERATOGENIC EFFECTS OF ETHANOL IN QUACKENBUSH SPECIAL MOUSE

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AMINI S.A.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2000 | Volume:2 | Issue:1 Page(s): 17-26

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Information Journal Paper

Title

TERATOGENIC EFFECTS OF ETHANOL IN QUACKENBUSH SPECIAL MOUSE

Author(s)

AMINI S.A. | Issue Writer Certificate

Keywords

ALCOHOLQ2

QS MOUSEQ4

OSSIFICATIONQ4

EMBRYOQ3

FETALQ3

Abstract

The intragastric exposure of Quackenbush Special (QS) mice to ALCOHOL both under short-term (6-day period, 3.0 g/kg, but not 1.5 g/kg, body weight/day through gestation days GD 7 to GD 12) and long-term (15% ethanol in drinking water beginning several weeks before mating and continuing in to pregnancy) conditions, reduced the weight, size, and protein content of GD 12 EMBRYOs, and the weight of GD 18 EMBRYOs. Compared to control, the incidence of brachydactyly with delayed OSSIFICATION was also significantly greater in EMBRYOs chronically exposed to ALCOHOL (45% vs. 6.7%). The short-term and long-term exposure regimens produced incidences of only 1% and 5.8% respectively, of forelimb ectrodactyly in GD 18 EMBRYOs. It was concluded that ALCOHOL exerts EMBRYO growth retarding effects in pregnant QS mice without inducing a high incidence of skeletal defects. Thus, the QS MOUSE could serve as an excellent model to resolve the mechanisms whereby ALCOHOL induces pre - and post-natal growth restrictions during pregnancy.

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APA: Copy

AMINI, S.A.. (2000). TERATOGENIC EFFECTS OF ETHANOL IN QUACKENBUSH SPECIAL MOUSE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 2(1), 17-26. SID. https://sid.ir/paper/58865/en

Vancouver: Copy

AMINI S.A.. TERATOGENIC EFFECTS OF ETHANOL IN QUACKENBUSH SPECIAL MOUSE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2000;2(1):17-26. Available from: https://sid.ir/paper/58865/en

IEEE: Copy

S.A. AMINI, “TERATOGENIC EFFECTS OF ETHANOL IN QUACKENBUSH SPECIAL MOUSE,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 2, no. 1, pp. 17–26, 2000, [Online]. Available: https://sid.ir/paper/58865/en

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