مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

290
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

99
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

CYTOCHROME P450 2C19 POLYMORPHISM IN IRANIAN PATIENTS WITH CORONARY ARTERY DISEASE

Pages

  106-110

Abstract

 BACKGROUND: The POLYMORPHISMs of cytochrome P450 2C19 (CYP2C19) gene are major prognostic factors for the response to CLOPIDOGREL therapy in patients with CORONARY ARTERY DISEASEs (CAD). The CYP2C19*2 is the most important allele responsible for resistance to CLOPIDOGREL therapy. This study examined CYP2C19 gene POLYMORPHISM (CYP2C19*1 and *2) in IRANian patients.METHODS: This cross-sectional study was performed on 43 IRANian patients with CAD who underwent percutaneous coronary intervention (PCI) and received drug-eluted stents (DES).CYP2C19 POLYMORPHISMs were assessed using real time PCR and frequency of CYP2C19*1 and CYP2C19*2 were determined, and then homo- or heterozygous state of genes was detected by Melt Curve Analysis method.RESULTS: Forty three patients (mean age=58.8±10.0 years, 79.1% male) participated in this study. CYP2C19*1/CYP2C19*1 genotype was observed in 31 (72.1%) of participates, CYP2C19*1/CYP2C19*2 genotype in 10 (23.3%), and CYP2C19*2/CYP2C19*2 genotype in 2 patients (4.7%). The frequency of CYP2C19*2 allele in the sample was 27.9%.CONCLUSION: This study demonstrated a high prevalence of CYP2C19*2 gene POLYMORPHISM in IRANian patients. Further studies with larger samples or longitudinal are required to determine the effects of this POLYMORPHISM on the prognosis of CAD patients in our population.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    AKHLAGHI, ARASH, SHIRANI, SHAHIN, ZIAIE, NAGHMEH, PIRHAJI, OMID, YARAN, MAJID, SHAHVERDI, GOLNOOSH, SARRAFZADEGAN, NIZAL, KHOSRAVI, ALIREZA, & KHOSRAVI, ELHAM. (2011). CYTOCHROME P450 2C19 POLYMORPHISM IN IRANIAN PATIENTS WITH CORONARY ARTERY DISEASE. ARYA ATHEROSCLEROSIS, 7(3), 106-110. SID. https://sid.ir/paper/589683/en

    Vancouver: Copy

    AKHLAGHI ARASH, SHIRANI SHAHIN, ZIAIE NAGHMEH, PIRHAJI OMID, YARAN MAJID, SHAHVERDI GOLNOOSH, SARRAFZADEGAN NIZAL, KHOSRAVI ALIREZA, KHOSRAVI ELHAM. CYTOCHROME P450 2C19 POLYMORPHISM IN IRANIAN PATIENTS WITH CORONARY ARTERY DISEASE. ARYA ATHEROSCLEROSIS[Internet]. 2011;7(3):106-110. Available from: https://sid.ir/paper/589683/en

    IEEE: Copy

    ARASH AKHLAGHI, SHAHIN SHIRANI, NAGHMEH ZIAIE, OMID PIRHAJI, MAJID YARAN, GOLNOOSH SHAHVERDI, NIZAL SARRAFZADEGAN, ALIREZA KHOSRAVI, and ELHAM KHOSRAVI, “CYTOCHROME P450 2C19 POLYMORPHISM IN IRANIAN PATIENTS WITH CORONARY ARTERY DISEASE,” ARYA ATHEROSCLEROSIS, vol. 7, no. 3, pp. 106–110, 2011, [Online]. Available: https://sid.ir/paper/589683/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button