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Information Journal Paper

Title

CANNABINOID CB1 RECEPTORS MEDIATE THE GASTRO PROTECTIVE EFFECT OF NEUROTENSIN

Pages

  803-810

Keywords

CB1 RECEPTORS 

Abstract

 Objective(s): Several lines of evidence indicate that neuropeptides exhibit protective properties against gastro duodenal ulcers. NEUROTENSIN, a gut-brain neuropeptide, is implicated in a number of physiological processes in the central nervous system and peripheral tissues including gastrointestinal tract. In the present study, we aimed to investigate the gastro protective potential of either peripherally or centrally administered NEUROTENSIN with a look at the role of the cannabinoid CB1 receptors which are located in brain areas implicated in the regulation of gastric functions. Materials and Methods: Gastric mucosal damage was induced by intragastric administration of acidified ethanol in male Wistar rats. One hour later, gastric lesions were evaluated macroscopically. In gastro protection study, NEUROTENSIN was administered either intravenously (1.5, 3, and 5 µM/kg) or intracerebroventricularly (0.5, 1, and 2.5 nM/rat) 30 min before the ethanol challenge. In order to evaluate the involvement of central CB1 receptors in the gastro protective effect of NEUROTENSIN, the CB1 receptor antagonist AM251 (5, 10, and 15 nM/rat) was given i.c.v. 30 min prior to the administration of NEUROTENSIN. The effects of AM251 on the intact stomach and ethanol-induced gastric lesions were also evaluated. Results: Acidified ethanol induced large areas of gastric lesions which were significantly reduced by the highest dose of NEUROTENSIN in i.v. or i.c.v. application. The gastro protective effect of NEUROTENSIN was prevented by pretreatment with 15 nM/rat AM251. AM251 had no effect by itself. Conclusion: Peripherally or centrally given NEUROTENSIN protects gastric mucosa against damage induced by acidified ethanol through the activation of central cannabinoid CB1 receptors.

Cites

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    • Cite

    APA: Copy

    HASSANZADEH, PARICHEHR, & ARBABI, ELHAM. (2012). CANNABINOID CB1 RECEPTORS MEDIATE THE GASTRO PROTECTIVE EFFECT OF NEUROTENSIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 15(3), 803-810. SID. https://sid.ir/paper/592322/en

    Vancouver: Copy

    HASSANZADEH PARICHEHR, ARBABI ELHAM. CANNABINOID CB1 RECEPTORS MEDIATE THE GASTRO PROTECTIVE EFFECT OF NEUROTENSIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2012;15(3):803-810. Available from: https://sid.ir/paper/592322/en

    IEEE: Copy

    PARICHEHR HASSANZADEH, and ELHAM ARBABI, “CANNABINOID CB1 RECEPTORS MEDIATE THE GASTRO PROTECTIVE EFFECT OF NEUROTENSIN,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 15, no. 3, pp. 803–810, 2012, [Online]. Available: https://sid.ir/paper/592322/en

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