Drug Resistance Patterns and Genotyping of Acinetobacter baumannii Strains Isolated from Patients Admitted to Shahrekord Teaching Hospitals Using REP-PCR

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Sarafan Sadeghi a.; ANSARI N.; KHADEMI F.; MIRNEJAD R.; ZAMANZAD B.

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Journal: Journal of Ardabil University of Medical Sciences Year:2019 | Volume:19 | Issue:1 Page(s): 30-40

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Title

Drug Resistance Patterns and Genotyping of Acinetobacter baumannii Strains Isolated from Patients Admitted to Shahrekord Teaching Hospitals Using REP-PCR

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Keywords

Acinetobacter baumanniiQ1

Antibiotic ResistanceQ2

GenotypingQ2

REP-PCRQ1

Abstract

Background & objectives: In recent years, Acinetobacter baumannii has been shown to be associated with several nosocomial infections, including pneumonia, bacteraemia, urinary tract infections, wound infection and meningitis. This organism can survive in the hospital environment and rapidly develops resistance to many antibiotics. The molecular Genotyping can increase our knowledge about the spread of A. baumannii strains from one hospital to another and their drug resistance. Therefore, this study aimed to determine the prevalence of Antibiotic Resistance profile as well as phylogenetic relationships of A. baumannii strains in Shahrekord teaching hospitals. Methods: In this study, antibacterial susceptibility patterns of A. baumannii strains isolated from different clinical specimens (urine, blood, sputum ) to amikacin, ampicillin/sulbactam, aztreonam, cefepime, ceftazidime, ciprofloxacin, gentamycin, imipenem, meropenem, norfloxacin, ofloxacin, piperacillin/tazobactam, tobramycin were tested using disk diffusion (Kirby-Bauer )method. Finally, Genotyping of A. baumannii strains was performed using REP-PCR method. Results: During this study, 50 samples of patients were identified as A. baumannii (71% ), and their drug resistance rates were assessed. All A. baumannii strains were resistant to ceftazidime and cefepime and also a high rate of resistance to aztreonam, norfloxacin, ciprofloxacin, amikacin, imipenem, gentamycin, and ampicillin-sulbactam were observed. On the other hand, our results demonstrated nine genotype groups among A. baumannii strains based on REP-PCR method. Conclusion: Due to the high prevalence of Antibiotic Resistance among isolated A. baumannii strains, similarities between different genotypes and the dispersion of these genotypes in different parts of Shahrekord hospitals, the implementation of infection control programs in different parts of the hospital is necessary.

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APA: Copy

Sarafan Sadeghi, a., ANSARI, N., KHADEMI, F., MIRNEJAD, R., & ZAMANZAD, B.. (2019). Drug Resistance Patterns and Genotyping of Acinetobacter baumannii Strains Isolated from Patients Admitted to Shahrekord Teaching Hospitals Using REP-PCR. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 19(1 ), 30-40. SID. https://sid.ir/paper/59695/en

Vancouver: Copy

Sarafan Sadeghi a., ANSARI N., KHADEMI F., MIRNEJAD R., ZAMANZAD B.. Drug Resistance Patterns and Genotyping of Acinetobacter baumannii Strains Isolated from Patients Admitted to Shahrekord Teaching Hospitals Using REP-PCR. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2019;19(1 ):30-40. Available from: https://sid.ir/paper/59695/en

IEEE: Copy

a. Sarafan Sadeghi, N. ANSARI, F. KHADEMI, R. MIRNEJAD, and B. ZAMANZAD, “Drug Resistance Patterns and Genotyping of Acinetobacter baumannii Strains Isolated from Patients Admitted to Shahrekord Teaching Hospitals Using REP-PCR,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 19, no. 1 , pp. 30–40, 2019, [Online]. Available: https://sid.ir/paper/59695/en

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