EFFECT OF EXERCISE PRECONDITIONING ON MEMORY DEFICITS AND NEURONAL CELL DEATH IN THE CA3 PYRAMIDAL CELLS OF THE RAT HIPPOCAMPUS FOLLOWING TRANSIENT GLOBAL CEREBRAL ISCHEMIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAMSAEI N.; ABOUTALEB N.; ERFANI S.; KHAKSARI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS) Year:2015 | Volume:15 | Issue:3 Page(s): 291-300

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,055

Download:

Cites:

Information Journal Paper

Title

EFFECT OF EXERCISE PRECONDITIONING ON MEMORY DEFICITS AND NEURONAL CELL DEATH IN THE CA3 PYRAMIDAL CELLS OF THE RAT HIPPOCAMPUS FOLLOWING TRANSIENT GLOBAL CEREBRAL ISCHEMIA

Author(s)

SHAMSAEI N. | ABOUTALEB N. | ERFANI S. | KHAKSARI M. | Issue Writer Certificate

Keywords

EXERCISEQ2

HIPPOCAMPUSQ2

ISCHEMIAQ2

REPERFUSIONQ1

CELL DEATHQ3

Abstract

Background & objectives: Brain ISCHEMIA leads to irreversible functional and structural damage in various regions of the brain, especially in the HIPPOCAMPUS. There is an evidence indicating the physical EXERCISE has neuroprotective effects and may decrease the cerebral ISCHEMIA/ REPERFUSION injury in rats. The purpose of this study was the study of the effect of EXERCISE preconditioning on memory deficits and neuronal CELL DEATH in CA3 pyramidal cells of the rat HIPPOCAMPUS following transient global ISCHEMIA.Methods: 21 male rats weighing 260-300 g were randomly selected and allocated into three groups (sham, ISCHEMIA and EXERCISE+ischemia). The rats in EXERCISE group were trained to run on a treadmill 5 days a week for 4 weeks. ISCHEMIA induced by occlusion both common carotid arteries (CCA) for 20 minutes. The passive avoidance memory test using a Shuttle box used to assess the impairment of memory. The amount of CELL DEATH was measured using cresyl violet staining method.Results: The results showed that cerebral ISCHEMIA is associated with memory impairment, and physical activity before ISCHEMIA improves ISCHEMIA-induced memory impairments significantly (p<0.05). In addition, ISCHEMIA leads to CELL DEATH in hippocampal CA3 area neurons and EXERCISE also reduces ISCHEMIA-induced CELL DEATH significantly (p<0.05).Conclusion: This study showed that EXERCISE, when is used as apreconditioning stimulant, has a neuroprotective effects against brain ISCHEMIA.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAMSAEI, N., ABOUTALEB, N., ERFANI, S., & KHAKSARI, M.. (2015). EFFECT OF EXERCISE PRECONDITIONING ON MEMORY DEFICITS AND NEURONAL CELL DEATH IN THE CA3 PYRAMIDAL CELLS OF THE RAT HIPPOCAMPUS FOLLOWING TRANSIENT GLOBAL CEREBRAL ISCHEMIA. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 15(3), 291-300. SID. https://sid.ir/paper/59776/en

Vancouver: Copy

SHAMSAEI N., ABOUTALEB N., ERFANI S., KHAKSARI M.. EFFECT OF EXERCISE PRECONDITIONING ON MEMORY DEFICITS AND NEURONAL CELL DEATH IN THE CA3 PYRAMIDAL CELLS OF THE RAT HIPPOCAMPUS FOLLOWING TRANSIENT GLOBAL CEREBRAL ISCHEMIA. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2015;15(3):291-300. Available from: https://sid.ir/paper/59776/en

IEEE: Copy

N. SHAMSAEI, N. ABOUTALEB, S. ERFANI, and M. KHAKSARI, “EFFECT OF EXERCISE PRECONDITIONING ON MEMORY DEFICITS AND NEURONAL CELL DEATH IN THE CA3 PYRAMIDAL CELLS OF THE RAT HIPPOCAMPUS FOLLOWING TRANSIENT GLOBAL CEREBRAL ISCHEMIA,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 15, no. 3, pp. 291–300, 2015, [Online]. Available: https://sid.ir/paper/59776/en

Related Journal Papers