EFFECT OF ALCOHOLIC SALVIA OFFICINALE EXTRACT ON ANALGESIA INDUCED BY HYOSCINE IN ADULT MALE WISTAR RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GOMAR A.; HOSSEINI A.; MIRAZI N.; GOMAR M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

878

Download:

Cites:

Information Journal Paper

Title

EFFECT OF ALCOHOLIC SALVIA OFFICINALE EXTRACT ON ANALGESIA INDUCED BY HYOSCINE IN ADULT MALE WISTAR RATS

Author(s)

GOMAR A. | HOSSEINI A. | MIRAZI N. | GOMAR M. | Issue Writer Certificate

Keywords

SALVIA OFFICINALEQ2

PAINQ2

HYOSCINEQ3

RATQ2

Abstract

Background & objectives: HYOSCINE (scopolamine) as an anticholinergic and antinociceptive drug, has some side effects. Recently, it has been received much attention to the interactions between synthetic drugs and herbal extracts and their pharmacological responses which made the possibility of using the minimum dose and low side effects. In this study, we evaluated the effect of SALVIA OFFICINALE extract, HYOSCINE and their combinationin management of PAIN in RATs.Methods: In this experimental study animals were divided randomly into eight groups (n=6). HYOSCINE (0.5, 1 and 5 mg/kg) administrated by intraperitoneal injection and extract (100 and 200 mg/kg) was administered by gavages one hour before administration of HYOSCINE. Thirty minutes after treatment, RATs were subjected to tail-flick test and data were recorded. Statistical significance was considered at p<0.05.Results: Administration of HYOSCINE at doses of 0.5, 1 and 5 mg/kg created significant analgesic effects compared to control group in the Tail-flick test (p<0.05, p<0.01 and p<0.05, respectively). The combination of S.officinale extract (100 and 200 mg/kg) and HYOSCINE (1 mg/kg) significantly increased the PAIN threshold than the groups receiving only extract or HYOSCINE.Conclusion: Our data showed that hydroethanolic extract of SALVIA OFFICINALE has an important antinociceptive effect which can lead to decreased PAIN in RATs. Sincehyoscine as an analgesic drug has some side effects, combination of SALVIA OFFICINALE extractand HYOSCINE can decrease the needed dose of HYOSCINE and itsside effects.

Cites

No record.

References

No record.

Cite

APA: Copy

GOMAR, A., HOSSEINI, A., MIRAZI, N., & GOMAR, M.. (2015). EFFECT OF ALCOHOLIC SALVIA OFFICINALE EXTRACT ON ANALGESIA INDUCED BY HYOSCINE IN ADULT MALE WISTAR RATS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 15(3), 237-245. SID. https://sid.ir/paper/59780/en

Vancouver: Copy

GOMAR A., HOSSEINI A., MIRAZI N., GOMAR M.. EFFECT OF ALCOHOLIC SALVIA OFFICINALE EXTRACT ON ANALGESIA INDUCED BY HYOSCINE IN ADULT MALE WISTAR RATS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2015;15(3):237-245. Available from: https://sid.ir/paper/59780/en

IEEE: Copy

A. GOMAR, A. HOSSEINI, N. MIRAZI, and M. GOMAR, “EFFECT OF ALCOHOLIC SALVIA OFFICINALE EXTRACT ON ANALGESIA INDUCED BY HYOSCINE IN ADULT MALE WISTAR RATS,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 15, no. 3, pp. 237–245, 2015, [Online]. Available: https://sid.ir/paper/59780/en

Related Journal Papers