RELATIONSHIP BETWEEN NEW ALLELIC TYPES OF HELICOBACTER PYLORI VACA GENE AND CAGA STATUS AND RISK OF GU OR DU IN IRAN

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BAKHTI S.Z.; LATIFI NAVID S.; ZAHRI S.; YAZDANBOD A.

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Journal: Journal of Ardabil University of Medical Sciences Year:2015 | Volume:15 | Issue:3 Page(s): 246-254

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Title

RELATIONSHIP BETWEEN NEW ALLELIC TYPES OF HELICOBACTER PYLORI VACA GENE AND CAGA STATUS AND RISK OF GU OR DU IN IRAN

Author(s)

BAKHTI S.Z. | LATIFI NAVID S. | ZAHRI S. | YAZDANBOD A. | Issue Writer Certificate

Keywords

HELICOBACTER PYLORIQ3

VACAQ2

CAGAQ1

GASTRIC ULCERQ3

DUODENAL ULCERQ2

IRANQ2

Abstract

Background & objectives: Several studies have described VACA and CAGA as the two important virulence determinants of HELICOBACTER PYLORI, which are associated with GASTRIC ULCER (GU) and DUODENAL ULCER (DU). The aim of present study was to determine the associations of the i and d regions genotypes of H. pylori VACA gene; and CAGA status with GU and DU risk.Methods: A total of 177 isolates were cultured from the biopsies of IRANian patients with different geographic origins and genotyped. Data were collected and analyzed.Results: Frequency of the VACA i1, i2, i1i2, d1, and d2 alleles and CAGA in all patients was 42.9%, 55.4%, 1.7%, 41.8%, 58.2% and 68.4%, respectively. There was a significant difference between the frequencies of VACA i1 in isolates from GU than those from nonatrophic gastritis (p<0.05). When the GU was considered as a dependant factor by the multiple logistic regression analysis, the VACA i1 genotype was significantly associated with the age- and sex-adjusted risk for GU (p=0.006, odds ratio [OR]=3.56; 95% confidence interval [CI]=1.45–8.75). Statistical analysis showed no significant association betweenvacA d genotype and digestive diseases. After controlling for age and sex variables, thecagA genotype remained in the final model when the DU was considered as a dependant factor by the the multiple logistic regression analysis (p=0.021, OR=3.77; 95% CI=1.22-11.60).Conclusion: We have proposed that the H. pylori VACA i1 and CAGA genotypes could be considered as benefit biomarkers for prediction of risk of GU and DU in IRAN, respectively.

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APA: Copy

BAKHTI, S.Z., LATIFI NAVID, S., ZAHRI, S., & YAZDANBOD, A.. (2015). RELATIONSHIP BETWEEN NEW ALLELIC TYPES OF HELICOBACTER PYLORI VACA GENE AND CAGA STATUS AND RISK OF GU OR DU IN IRAN. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 15(3), 246-254. SID. https://sid.ir/paper/59781/en

Vancouver: Copy

BAKHTI S.Z., LATIFI NAVID S., ZAHRI S., YAZDANBOD A.. RELATIONSHIP BETWEEN NEW ALLELIC TYPES OF HELICOBACTER PYLORI VACA GENE AND CAGA STATUS AND RISK OF GU OR DU IN IRAN. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2015;15(3):246-254. Available from: https://sid.ir/paper/59781/en

IEEE: Copy

S.Z. BAKHTI, S. LATIFI NAVID, S. ZAHRI, and A. YAZDANBOD, “RELATIONSHIP BETWEEN NEW ALLELIC TYPES OF HELICOBACTER PYLORI VACA GENE AND CAGA STATUS AND RISK OF GU OR DU IN IRAN,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 15, no. 3, pp. 246–254, 2015, [Online]. Available: https://sid.ir/paper/59781/en

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