EFFECT OF SIMULATED INTERMITTENT ALTITUDE ON THE METABOLIC AND HEMATOLOGIC PARAMETERS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

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FARAMOUSHI M.; AMIR SASAN R.; SARI SARRAF V.; KARIMI P.

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Journal: Journal of Ardabil University of Medical Sciences Year:2016 | Volume:16 | Issue:1 Page(s): 53-64

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Title

EFFECT OF SIMULATED INTERMITTENT ALTITUDE ON THE METABOLIC AND HEMATOLOGIC PARAMETERS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Author(s)

FARAMOUSHI M. | AMIR SASAN R. | SARI SARRAF V. | KARIMI P. | Issue Writer Certificate

Keywords

ALTITUDEQ2

BLOOD GLUCOSEQ3

HEMATOLOGYQ2

WISTAR RATSQ2

TYPE II DIABETESQ2

Abstract

Background & objectives: TYPE II DIABETES is a metabolic disorder accompanied with insulin resistance of the whole body cells and is considered be the fifth cause of death in the world.Adaptation to ALTITUDE can lead to tolerance to many diseases. Therefore, the aim of this study was to determine the effect of simulated intermittent ALTITUDE on the metabolic and hematologic parameters and liver function in streptozotocin induced diabetic rats.Methods: In the current experimental study, twenty four male WISTAR RATS weighing 220𩣁20 gr were randomly divided into three groups; normal control group (NC, n=8), diabetic control group (D, n=8) received fat diet for 2 weeks then were injected with streptozotocin (37 mg/kg) and diabetic+hypoxia group (D+H, n=8) including diabetic rat exposed to chronic intermittent hypoxia (PiO2»106 mm Hg, simulated ALTITUDE »3400 m, 14% oxygen for 8 weeks). Diabetic, hematologic and lipid parameters as well as ALT and AST activities were measured in peripheral blood.Results: Our findings showed that intermittent hypoxia significantly decreased serum total cholesterol, LDL, VLDL and triglyceride in D+H group compared to D group (p<0.05).Serum levels of fasting BLOOD GLUCOSE and homeostatic model assessment-insulin resistance (HOMA-IR) index and ALT were decreased in D+H group vs. D group (p<0.05). Also, hemoglubin and hematocrite level increased in D+H group in comparison to D group (p<0.05). No significant difference was detected in red blood cell count in D+H vs. D group.Conclusion: Based on resultant data, it seems that intermittent exposure to hypoxia (simulated to chronic and intermittent lodgement in ALTITUDE) can be used to control of type 2 diabetes by increasing hemoglobin, decreasing insulin resistance and improving liver function as well as lipid parameters.

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APA: Copy

FARAMOUSHI, M., AMIR SASAN, R., SARI SARRAF, V., & KARIMI, P.. (2016). EFFECT OF SIMULATED INTERMITTENT ALTITUDE ON THE METABOLIC AND HEMATOLOGIC PARAMETERS IN STREPTOZOTOCIN INDUCED DIABETIC RATS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 16(1), 53-64. SID. https://sid.ir/paper/59790/en

Vancouver: Copy

FARAMOUSHI M., AMIR SASAN R., SARI SARRAF V., KARIMI P.. EFFECT OF SIMULATED INTERMITTENT ALTITUDE ON THE METABOLIC AND HEMATOLOGIC PARAMETERS IN STREPTOZOTOCIN INDUCED DIABETIC RATS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2016;16(1):53-64. Available from: https://sid.ir/paper/59790/en

IEEE: Copy

M. FARAMOUSHI, R. AMIR SASAN, V. SARI SARRAF, and P. KARIMI, “EFFECT OF SIMULATED INTERMITTENT ALTITUDE ON THE METABOLIC AND HEMATOLOGIC PARAMETERS IN STREPTOZOTOCIN INDUCED DIABETIC RATS,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 16, no. 1, pp. 53–64, 2016, [Online]. Available: https://sid.ir/paper/59790/en

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