THE EFFECTS OF VITEX AGNUS CASTUS EXTRACT AND INTERACTION WITH BROMOCRIPTINE ON LUTEINIZING HORMONE AND TESTOSTERONE IN MALE MICE

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NASRI S.; ORYAN SHAHRBANOU; HAERI ROUHANI SEYED ALI; AMIN GHOLAM REZA; TAGHIZADEH M.A.

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Journal: Hormozgan Medical Journal Year:2005 | Volume:9 | Issue:2 Page(s): 113-118

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Title

THE EFFECTS OF VITEX AGNUS CASTUS EXTRACT AND INTERACTION WITH BROMOCRIPTINE ON LUTEINIZING HORMONE AND TESTOSTERONE IN MALE MICE

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Keywords

MICEQ3

LHQ2

TESTOSTERONEQ2

BROMCRIPTINEQ3

Abstract

Introduction: Several clinical studies have confirmed the beneficial effect of plants extracts in the treatment of disorders. The purpose of this study was to evaluate the probable effects of vitex agnus-castus (VAC) on the male reproductive physiology, and also the dopaminergic agonist (Bromocriptine) on male MICE.Methods: In this experimental study, in order to evaluate, the medicinal effects of vitex agnus castus, we used the hydroalcoholic VAC. Extract injection with the following doses: 65, 165, 265, 365 and 465 mg/kg; bromocriptine as a dopamine agonist receptor (5, 10, 20 mg/kg). To study the interaction between VAC. Extract and bromocriptine, we injected the optimum doses of VAC. With bromocriptine at the same time. Intraperitoneal injections were applied in all experiments, once a day for 30 days. The control group remained intact and the sham group received vehicle. After the last injection, we collected the animal blood serums for hormonal assays. For statistical analysis, analysis of variance was used and P<0.05 was considered significant.Results: LH and testostrone showed significant decrease in bromocriptine group. VAC. Extract decreased significantly the LH and TESTOSTERONE levels. The coadministration of VAC. Extract and bromocriptine decreased LH and TESTOSTERONE.Conclusion: These results suggest: Dopamine regulates the gonadotroph- Leyding cells axis. It appears that VAC. Extract effects through dopaminergic system and other pathways.

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APA: Copy

NASRI, S., ORYAN, SHAHRBANOU, HAERI ROUHANI, SEYED ALI, AMIN, GHOLAM REZA, & TAGHIZADEH, M.A.. (2005). THE EFFECTS OF VITEX AGNUS CASTUS EXTRACT AND INTERACTION WITH BROMOCRIPTINE ON LUTEINIZING HORMONE AND TESTOSTERONE IN MALE MICE. HORMOZGAN MEDICAL JOURNAL, 9(2), 113-118. SID. https://sid.ir/paper/60165/en

Vancouver: Copy

NASRI S., ORYAN SHAHRBANOU, HAERI ROUHANI SEYED ALI, AMIN GHOLAM REZA, TAGHIZADEH M.A.. THE EFFECTS OF VITEX AGNUS CASTUS EXTRACT AND INTERACTION WITH BROMOCRIPTINE ON LUTEINIZING HORMONE AND TESTOSTERONE IN MALE MICE. HORMOZGAN MEDICAL JOURNAL[Internet]. 2005;9(2):113-118. Available from: https://sid.ir/paper/60165/en

IEEE: Copy

S. NASRI, SHAHRBANOU ORYAN, SEYED ALI HAERI ROUHANI, GHOLAM REZA AMIN, and M.A. TAGHIZADEH, “THE EFFECTS OF VITEX AGNUS CASTUS EXTRACT AND INTERACTION WITH BROMOCRIPTINE ON LUTEINIZING HORMONE AND TESTOSTERONE IN MALE MICE,” HORMOZGAN MEDICAL JOURNAL, vol. 9, no. 2, pp. 113–118, 2005, [Online]. Available: https://sid.ir/paper/60165/en

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