EFFECTIVENESS OF EVERY OTHER DAY GENTAMICIN INJECTION IN TREATMENT OF URINARY TRACT INFECTION IN RAT

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EMAM GHOREYSHI F.; OUJI M.; KOHANTEB Y.; TANIDEH N.

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Title

EFFECTIVENESS OF EVERY OTHER DAY GENTAMICIN INJECTION IN TREATMENT OF URINARY TRACT INFECTION IN RAT

Author(s)

EMAM GHOREYSHI F. | OUJI M. | KOHANTEB Y. | TANIDEH N. | Issue Writer Certificate

Keywords

URINARY TRACT INFECTIONQ2

RATSQ4

GENTAMICINQ3

Abstract

Introduction: Aminoglycoside is a common antibiotic in treatment of URINARY TRACT INFECTION. Their dosages and interval were changed during years. The last recommendation is daily administration. In the present study, we evaluated effectiveness of every other day GENTAMICIN usage in treatment of URINARY TRACT INFECTION in experimental model.Methods: In this experimental study, 48 Sperague Dawley RATS were infected by inoculation if 0.1 ml E-coli suspension 109 to left kidney. GENTAMICIN was administrated intraperitoneal in different dosages and interval as 10mg/kg daily, 10mg/kg and 20mg/kg every other day. Responses were evaluated after one week by colony forming units/ml and percent of sterile kidney. Chi-Square and analysis of variance statistical tests were used for data analysis and P < 0.05 was considered statistically significant.Results: The result showed no significant difference between responses in various groups. Colony counts and percent of sterile kidney were not different in groups. Histological changes showed no difference in scar formation between three first groups, but sever scar formation in the forth group (P<0.0001). Conclusion: GENTAMICIN usage with every other day interval could be effective as daily injection, without increase in scar formation. More studies on this is use is recommended.

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APA: Copy

EMAM GHOREYSHI, F., OUJI, M., KOHANTEB, Y., & TANIDEH, N.. (2005). EFFECTIVENESS OF EVERY OTHER DAY GENTAMICIN INJECTION IN TREATMENT OF URINARY TRACT INFECTION IN RAT. HORMOZGAN MEDICAL JOURNAL, 9(2), 125-130. SID. https://sid.ir/paper/60170/en

Vancouver: Copy

EMAM GHOREYSHI F., OUJI M., KOHANTEB Y., TANIDEH N.. EFFECTIVENESS OF EVERY OTHER DAY GENTAMICIN INJECTION IN TREATMENT OF URINARY TRACT INFECTION IN RAT. HORMOZGAN MEDICAL JOURNAL[Internet]. 2005;9(2):125-130. Available from: https://sid.ir/paper/60170/en

IEEE: Copy

F. EMAM GHOREYSHI, M. OUJI, Y. KOHANTEB, and N. TANIDEH, “EFFECTIVENESS OF EVERY OTHER DAY GENTAMICIN INJECTION IN TREATMENT OF URINARY TRACT INFECTION IN RAT,” HORMOZGAN MEDICAL JOURNAL, vol. 9, no. 2, pp. 125–130, 2005, [Online]. Available: https://sid.ir/paper/60170/en

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