ANALGESIC AND ULCEROGENIC EFFECT OF METHANOLIC EXTRACT OF MELILOTUS OFFICINALIS

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HEYDARI MAHMOUD REZA; NAJAFI FARIBA; ASADIPOUR A.; ANSARI MAHDI; ZAHEDI M.J.; VAHEDIAN MOHAMMAD

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Journal: Journal of Kerman University of Medical Sciences Year:2001 | Volume:8 | Issue:4 Page(s): 210-219

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Title

ANALGESIC AND ULCEROGENIC EFFECT OF METHANOLIC EXTRACT OF MELILOTUS OFFICINALIS

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Keywords

MEDICINAL PLANTSQ2

MELILOTUS OFFICINALISQ3

PAIN MEASUREMENTQ2

Abstract

In traditional medicine, some plants are used as analgesic. The aim of this investigation was to evaluate the analgesic effect of "Melilotus Officinalis", which is used traditionally to relieve rheumatic pain, migrain and as anti-inflammatory agent. For this purpose different doses of the suxheleted and percolated extract of melilotus officinal is, were injected intraperitoneally to mice and the analgesic effect was determined by tail flick and formalin tests. The results showed that, suxheleted methanolic extract with doses of 50, 100, 200 and 300mg/kg induced significant analgesia effect in comparison with the control group (P<0.01). The maximum analgesic effect was observed in 200mg/kg which reached to its peak at 120 min after injection (P<0. 01). Analgesic effect of suxheleted extract was higher than percolated one. Pretreatment of animals with naloxane did not change the analgesic effect of the extract; therefore the involvement of opioid receptors was excluded in this respect. The ulcerogenicity test showed that the ulcerogenic effect of the extract was lower than that of the same dose of indomethacine. Overall the results indicated that the extract of the plant had analgesic effect.

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APA: Copy

HEYDARI, MAHMOUD REZA, NAJAFI, FARIBA, ASADIPOUR, A., ANSARI, MAHDI, ZAHEDI, M.J., & VAHEDIAN, MOHAMMAD. (2001). ANALGESIC AND ULCEROGENIC EFFECT OF METHANOLIC EXTRACT OF MELILOTUS OFFICINALIS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 8(4), 210-219. SID. https://sid.ir/paper/605/en

Vancouver: Copy

HEYDARI MAHMOUD REZA, NAJAFI FARIBA, ASADIPOUR A., ANSARI MAHDI, ZAHEDI M.J., VAHEDIAN MOHAMMAD. ANALGESIC AND ULCEROGENIC EFFECT OF METHANOLIC EXTRACT OF MELILOTUS OFFICINALIS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;8(4):210-219. Available from: https://sid.ir/paper/605/en

IEEE: Copy

MAHMOUD REZA HEYDARI, FARIBA NAJAFI, A. ASADIPOUR, MAHDI ANSARI, M.J. ZAHEDI, and MOHAMMAD VAHEDIAN, “ANALGESIC AND ULCEROGENIC EFFECT OF METHANOLIC EXTRACT OF MELILOTUS OFFICINALIS,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 4, pp. 210–219, 2001, [Online]. Available: https://sid.ir/paper/605/en

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