RENOPROTECTIVE EFFECTS OF GABA ON ISCHEMIA/REPERFUSION- INDUCED RENAL INJURY IN HYPERGLYCEMIC MALE AND FEMALE RATS

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SOLTANI NEPTON; TIGHSAZ YOUSEF; NEMATBAKHSH MEHDI

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Journal: Hormozgan Medical Journal Year:2017 | Volume:21 | Issue:1 Page(s): 1-9

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Title

RENOPROTECTIVE EFFECTS OF GABA ON ISCHEMIA/REPERFUSION- INDUCED RENAL INJURY IN HYPERGLYCEMIC MALE AND FEMALE RATS

Author(s)

SOLTANI NEPTON | TIGHSAZ YOUSEF | NEMATBAKHSH MEHDI | Issue Writer Certificate

Keywords

ISCHEMIAQ2

REPERFUSIONQ1

DIABETESQ2

GABAQ2

RATQ2

Abstract

Introduction: Acute kidney injury (AKI) has been known as a complex clinical complication in diabetic patients. The main cause of AKI is ISCHEMIA/reperfusion injury (IRI). This study was designed to investigate the protective effects of GABA on renal IRI in hyperglycemic female and male RATs.Methods: Sixty STZ induced diabetic male and female Wistar RATs were categorized in 10 groups (5 female & 5 male groups). Groups 1-3 in each gender received GABA (10, 50, 100μmol/kg/day) for 3 days, and then were subjected to renal IRI.Group 4 in each gender was subjected to renal IRI alone, and group 5 was subjected to surgical operation without renal IRI.24 hr after I/R injury, blood sample was obtained, and the animal were sacrificed for pathology investigation.Results: Renal IRI alone increased the serum blood urea nitrogen levels (BUN) and creatinine (Cr), and kidney damage in both male and female RATs significantly (P<0.05), however all doses of GABA decreased the serum BUN and Cr levels and tissue damage when compared with control group.Conclusion: From the results of this study it seems that GABA administration in hyperglycemic RATs could decrease renal injury after an ISCHEMIA/reperfusion.

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APA: Copy

SOLTANI, NEPTON, TIGHSAZ, YOUSEF, & NEMATBAKHSH, MEHDI. (2017). RENOPROTECTIVE EFFECTS OF GABA ON ISCHEMIA/REPERFUSION- INDUCED RENAL INJURY IN HYPERGLYCEMIC MALE AND FEMALE RATS. HORMOZGAN MEDICAL JOURNAL, 21(1), 1-9. SID. https://sid.ir/paper/60569/en

Vancouver: Copy

SOLTANI NEPTON, TIGHSAZ YOUSEF, NEMATBAKHSH MEHDI. RENOPROTECTIVE EFFECTS OF GABA ON ISCHEMIA/REPERFUSION- INDUCED RENAL INJURY IN HYPERGLYCEMIC MALE AND FEMALE RATS. HORMOZGAN MEDICAL JOURNAL[Internet]. 2017;21(1):1-9. Available from: https://sid.ir/paper/60569/en

IEEE: Copy

NEPTON SOLTANI, YOUSEF TIGHSAZ, and MEHDI NEMATBAKHSH, “RENOPROTECTIVE EFFECTS OF GABA ON ISCHEMIA/REPERFUSION- INDUCED RENAL INJURY IN HYPERGLYCEMIC MALE AND FEMALE RATS,” HORMOZGAN MEDICAL JOURNAL, vol. 21, no. 1, pp. 1–9, 2017, [Online]. Available: https://sid.ir/paper/60569/en

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