DECREASE IN BLOOD FLOW AND TEMPERATURE OF RAT KNEE JOINT BY CALCIUM CHANNEL BLOCKERS IN CHRONIC INFLAMMATION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAKSARI HADAD M.; RAHMANI M.R.; ASADI KARAM GH.R.; HAJIZADEH S.; SHAHRANI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Hormozgan Medical Journal Year:2007 | Volume:10 | Issue:4 Page(s): 311-319

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

818

Download:

Cites:

Information Journal Paper

Title

DECREASE IN BLOOD FLOW AND TEMPERATURE OF RAT KNEE JOINT BY CALCIUM CHANNEL BLOCKERS IN CHRONIC INFLAMMATION

Author(s)

Keywords

RATSQ3

KNEE JOINTQ3

BLOOD FLOW VELOCITYQ3

INFLAMMATIONQ2

CALCIUM CHANNEL BLOCKERSQ3

Abstract

Introduction: The Blood flow increases in the inflamed joint induced by Complete Freund's Adjuvant (CFA). Since the anti-inflammatory effect of CALCIUM CHANNEL BLOCKERS have been shown in pervious studies, the present study investigates the role of these blockers on the blood flow and temperature (inflammation indices) in inflamed KNEE JOINT induced by CFA. Methods: This experimental study was carried out in 8 groups of adult male RATS. In group I, 0.2 ml of CFA solution was injected into the right knee, and group II received the same volume of normal saline. Group III to VIII received the same volume of CFA solution, but seven days after injection of CFA to the end of study, received the following drugs orally by oropharyngeal tubes. Group III dimethylsulfoxide (the drugs solvent), group IV and V received low dose (100 mg/kg) of verapamil and nifedipine respectively. Group VI and VII received high dose (800 mg/kg) of verapamil and nifedipine respectively, and group VIII was treated with ibuprofen (15mg/kg). The changes in blood flow and local temperature of the animal's KNEE JOINT were measured for 28 days after CFA injection. Results: CFA injection increased blood flow significantly in all 28 days compared to day zero, where as at seventh day increase in blood flow was 121.8±6.1 percent. Low dose of verapamil and nifedipine increased CFAinduced blood flow. The high dose of verapamil and nifedipine also diminished the blood flow of the knee. The inhibition effect of these blockers on KNEE JOINT blood flow was comparable to ibuprofen. Decrease in temperature by different doses of verapamil and nifedipine were not significant.Conclusion: The results of this study show that CALCIUM CHANNEL BLOCKERS inhibit the increased blood flow and temperature in chronic INFLAMMATION induced by CFA injection in the inflamed region. So these blockers possibly reduce the chronic INFLAMMATION by this mechanism.

Cites

No record.

References

Cite

APA: Copy

KHAKSARI HADAD, M., RAHMANI, M.R., ASADI KARAM, GH.R., HAJIZADEH, S., & SHAHRANI, M.. (2007). DECREASE IN BLOOD FLOW AND TEMPERATURE OF RAT KNEE JOINT BY CALCIUM CHANNEL BLOCKERS IN CHRONIC INFLAMMATION. HORMOZGAN MEDICAL JOURNAL, 10(4), 311-319. SID. https://sid.ir/paper/60775/en

Vancouver: Copy

KHAKSARI HADAD M., RAHMANI M.R., ASADI KARAM GH.R., HAJIZADEH S., SHAHRANI M.. DECREASE IN BLOOD FLOW AND TEMPERATURE OF RAT KNEE JOINT BY CALCIUM CHANNEL BLOCKERS IN CHRONIC INFLAMMATION. HORMOZGAN MEDICAL JOURNAL[Internet]. 2007;10(4):311-319. Available from: https://sid.ir/paper/60775/en

IEEE: Copy

M. KHAKSARI HADAD, M.R. RAHMANI, GH.R. ASADI KARAM, S. HAJIZADEH, and M. SHAHRANI, “DECREASE IN BLOOD FLOW AND TEMPERATURE OF RAT KNEE JOINT BY CALCIUM CHANNEL BLOCKERS IN CHRONIC INFLAMMATION,” HORMOZGAN MEDICAL JOURNAL, vol. 10, no. 4, pp. 311–319, 2007, [Online]. Available: https://sid.ir/paper/60775/en

Related Journal Papers