EFFECTS OF ALENDRONATE AND HORMONE REPLACEMENT THERAPY (HRT) ON BONE MINERAL DENSITY OF POSTMENOPAUSAL WOMEN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHARIFI FARANAK; PARSEH L.; AHMADI GHOLAM REZA; MOUSAVINASAB S.N.A.D.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Advances in Medical and Biomedical Research Year:2008 | Volume:15 | Issue:61 Page(s): 49-58

Download Full-Text

Persian Verion

View:

1,646

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF ALENDRONATE AND HORMONE REPLACEMENT THERAPY (HRT) ON BONE MINERAL DENSITY OF POSTMENOPAUSAL WOMEN

Author(s)

SHARIFI FARANAK | PARSEH L. | AHMADI GHOLAM REZA | MOUSAVINASAB S.N.A.D. | Issue Writer Certificate

Keywords

BONE DENSITYQ3

ALENDRONATEQ3

OSTEOPOROSISQ3

HRTQ3

CALCIUMQ3

VITAMIN DQ3

Abstract

Background and Objective: Although there are several methods of treatment of OSTEOPOROSIS, prospective studies to compare their effect on BONE DENSITY in Iranian population are rare. This study was designed to compare the effect of ALENDRONATE and hormone replacement therapy on bone mineral density of postmenopausal Iranian women living in Zanjan.Materials and Methods: We treated 115 women (mean age 54.8±9 years). Twenty four women were treated with conjugated equine estrogen (0.625 mg), 5 mg medroxyprogesterone, and 1000 mg elemental CALCIUM with 400 IU VITAMIN D daily. Forty four subjects received 10 mg/d ALENDRONATE plus CALCIUM and VITAMIN D in the same dose and 37 women were taken placebo with 1000 mg/d CALCIUM and 400 IU/d VITAMIN D. Their bone mineral densities (BMD) were measured at the lumbar spine, hip and mid radius every 12 months for three years. All cases with secondary OSTEOPOROSIS were excluded from the study.Results: Significantly a higher percentage increases in BMD at the lumbar spine (P<0.008, 2-way analysis of variance) were found in the ALENDRONATE group than in the HRT and CALCIUM + VITAMIN D groups throughout the 36-month study period. However, there was no difference in BMD at the femoral neck and mid-radius between ALENDRONATE and HRT groups. Treatment with ALENDRONATE resulted in an 11% increase at the L-spine BMD (P: 0.00). A non significant reduction of about 4% at the femoral neck BMD was detected in ALENDRONATE group at the end of the 3-year study period. Although there was no significant change in the femoral neck, lumbar spine or mid-radius BMD with HRT, a significant decline (about 9%) in the BMD of the femoral neck was observed in the placebo group (P: 0.004). There was no difference in upper gastrointestinal or drug-related side effects between the groups.Conclusion: Our data suggest that the use of ALENDRONATE was well tolerated for 3 years and significantly increased BMD at the L-spine. It also can reduce the rate of BMD reduction at the femoral neck as was seen in the placebo group in postmenopausal Iranian women. Although HRT can inhibit BMD reduction at the femoral neck and lumbar spine, this regimen can not increase BMD in postmenopausal Iranian women.

Cites

No record.

References

Cite

APA: Copy

SHARIFI, FARANAK, PARSEH, L., AHMADI, GHOLAM REZA, & MOUSAVINASAB, S.N.A.D.. (2008). EFFECTS OF ALENDRONATE AND HORMONE REPLACEMENT THERAPY (HRT) ON BONE MINERAL DENSITY OF POSTMENOPAUSAL WOMEN. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 15(61), 49-58. SID. https://sid.ir/paper/61033/en

Vancouver: Copy

SHARIFI FARANAK, PARSEH L., AHMADI GHOLAM REZA, MOUSAVINASAB S.N.A.D.. EFFECTS OF ALENDRONATE AND HORMONE REPLACEMENT THERAPY (HRT) ON BONE MINERAL DENSITY OF POSTMENOPAUSAL WOMEN. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2008;15(61):49-58. Available from: https://sid.ir/paper/61033/en

IEEE: Copy

FARANAK SHARIFI, L. PARSEH, GHOLAM REZA AHMADI, and S.N.A.D. MOUSAVINASAB, “EFFECTS OF ALENDRONATE AND HORMONE REPLACEMENT THERAPY (HRT) ON BONE MINERAL DENSITY OF POSTMENOPAUSAL WOMEN,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 15, no. 61, pp. 49–58, 2008, [Online]. Available: https://sid.ir/paper/61033/en

Related Journal Papers