METFORMIN EFFECT ON THE MOUSE PANCREATIC LANGERHANS ISLETS VOLUME

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KHORSANDI L.S.; BAHRAMZADEH S.; HASHEMITABAR M.; KALANTAR MAHDAVI S.A.R.D.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2011 | Volume:19 | Issue:74 Page(s): 9-16

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Title

METFORMIN EFFECT ON THE MOUSE PANCREATIC LANGERHANS ISLETS VOLUME

Author(s)

KHORSANDI L.S. | BAHRAMZADEH S. | HASHEMITABAR M. | KALANTAR MAHDAVI S.A.R.D. | Issue Writer Certificate

Keywords

METFORMINQ2

PANCREASQ2

ISLETS OF LANGERHANSQ3

MICEQ2

Abstract

Background and Objective: METFORMIN is a widely used medicine for treatment of type 2 diabetes. In this study, the effect of various doses of METFORMIN on the mouse ISLETS OF LANGERHANS volume was investigated. Materials and methods: Twenty four C57BL/6 adult male MICE weighting 30±5 gr were randomly divided into 4 groups. Normal saline was given to the control group (group 4) and the experimental groups (groups 1-3) received 75, 150 and 300 mg/kg METFORMIN daily by intraperitoneal injection for seven days. One day after the last injection the MICE were sacrificed by cervical dislocation and their PANCREASes were fixed in 10% formalin for histological studies. The volume of the ISLETS OF LANGERHANS was estimated by using Cavalieri method. Results: Volume of the ISLETS OF LANGERHANS in doses of 75 and 150 mg/kg METFORMIN showed a non-significant difference in comparison to control group (P>0.05). 300 mg/kg METFORMIN treated MICE showed a significant increase in ISLETS OF LANGERHANS volume compared to the control group (P<0.05).Conclusion: METFORMIN increases in the ISLETS OF LANGERHANS volume in a dose-dependent manner. Increasing effects of METFORMIN on the ISLETS OF LANGERHANS volume may be due to proliferation or hypertrophy of beta cells.

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APA: Copy

KHORSANDI, L.S., BAHRAMZADEH, S., HASHEMITABAR, M., & KALANTAR MAHDAVI, S.A.R.D.. (2011). METFORMIN EFFECT ON THE MOUSE PANCREATIC LANGERHANS ISLETS VOLUME. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 19(74), 9-16. SID. https://sid.ir/paper/61196/en

Vancouver: Copy

KHORSANDI L.S., BAHRAMZADEH S., HASHEMITABAR M., KALANTAR MAHDAVI S.A.R.D.. METFORMIN EFFECT ON THE MOUSE PANCREATIC LANGERHANS ISLETS VOLUME. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2011;19(74):9-16. Available from: https://sid.ir/paper/61196/en

IEEE: Copy

L.S. KHORSANDI, S. BAHRAMZADEH, M. HASHEMITABAR, and S.A.R.D. KALANTAR MAHDAVI, “METFORMIN EFFECT ON THE MOUSE PANCREATIC LANGERHANS ISLETS VOLUME,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 19, no. 74, pp. 9–16, 2011, [Online]. Available: https://sid.ir/paper/61196/en

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