INVOLVEMENT OF D1/D2 RECEPTORS ON 1-METHYL-B-CARBOLINE (HARMANE) INDUCED-AMNESIA IN THE STEP-DOWN PASSIVE AVOIDANCE TEST

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NASEHI M.; PIRI M.; SHAHIN M.; ZARRINDAST M.R.

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Title

INVOLVEMENT OF D1/D2 RECEPTORS ON 1-METHYL-B-CARBOLINE (HARMANE) INDUCED-AMNESIA IN THE STEP-DOWN PASSIVE AVOIDANCE TEST

Author(s)

NASEHI M. | PIRI M. | SHAHIN M. | ZARRINDAST M.R. | Issue Writer Certificate

Keywords

HARMANEQ3

APOMORPHINEQ3

SCH23390Q2

SULPIRIDEQ2

STEP-DOWN PASSIVE AVOIDANCE TASKQ3

MICEQ3

Abstract

Background and Objective: A number of β-carboline alkaloids such as HARMANE are naturally present in the human food chain. In the present study the involvement of dopaminergic system on HARMANE inducedamnesia was investigated.Materials and Methods: One-trial step-down paradigm was used for the assessment of memory retention in adult male NMRI MICE.Results: Intraperitoneal (i.p.) administration of HARMANE (5 and 10 mg/kg) immediately after training, dosedependently decreased memory formation. Administration of D1/D2 receptors agonist, APOMORPHINE (0.5 and 1 mg/kg, i.p.) before testing by itself could not alter memory retrieval. On the other hand, in the animals in which memory formation was impaired due to HARMANE post-training administration, pre-test administration of APOMORPHINE (0.5 and 1 mg/kg, i.p.) 24 hr after training in day's test restored memory. Furthermore, administration of SCH23390 (0.025, 0.05 and 0.1 mg/kg, i.p.) or SULPIRIDE (12.5, 25 and 50 mg/kg, i.p.) before testing by itself could not alter memory retrieval, respectively. On the other hand in the animals in which memory formation was impaired due to HARMANE post-training injection, pre-test administration of SCH23390 (0.05 and 0.1 mg/kg) or SULPIRIDE (25, 50 mg/kg, i.p.) 24 hr after training in day's test decreased hamane-induced amnesia.Conclusion: These findings indicat the involvement of D1/D2 receptors in HARMANE induced-amnesia through different mechanism(s).

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APA: Copy

NASEHI, M., PIRI, M., SHAHIN, M., & ZARRINDAST, M.R.. (2010). INVOLVEMENT OF D1/D2 RECEPTORS ON 1-METHYL-B-CARBOLINE (HARMANE) INDUCED-AMNESIA IN THE STEP-DOWN PASSIVE AVOIDANCE TEST. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 18(72), 1-12. SID. https://sid.ir/paper/61265/en

Vancouver: Copy

NASEHI M., PIRI M., SHAHIN M., ZARRINDAST M.R.. INVOLVEMENT OF D1/D2 RECEPTORS ON 1-METHYL-B-CARBOLINE (HARMANE) INDUCED-AMNESIA IN THE STEP-DOWN PASSIVE AVOIDANCE TEST. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2010;18(72):1-12. Available from: https://sid.ir/paper/61265/en

IEEE: Copy

M. NASEHI, M. PIRI, M. SHAHIN, and M.R. ZARRINDAST, “INVOLVEMENT OF D1/D2 RECEPTORS ON 1-METHYL-B-CARBOLINE (HARMANE) INDUCED-AMNESIA IN THE STEP-DOWN PASSIVE AVOIDANCE TEST,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 18, no. 72, pp. 1–12, 2010, [Online]. Available: https://sid.ir/paper/61265/en

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