EFFECT OF THE CHOLESTERYL ESTER TRANSFER PROTEIN I405V POLYMORPHISM ON THE LIPID RESPONSE TO CHANGES OF DIETARY FATTY ACID COMPOSITION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DARABI MASOUD; ABOU ALFATHI A.A.; OSTAD RAHIMI A.R.; KAZEMI ABD ALHASAN; SHAKER M.; NOURI MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Advances in Medical and Biomedical Research Year:2010 | Volume:17 | Issue:69 Page(s): 54-61

Download Full-Text

Persian Verion

View:

621

Download:

Cites:

Information Journal Paper

Title

EFFECT OF THE CHOLESTERYL ESTER TRANSFER PROTEIN I405V POLYMORPHISM ON THE LIPID RESPONSE TO CHANGES OF DIETARY FATTY ACID COMPOSITION

Author(s)

Keywords

HIGH DENSITY LIPOPROTEINQ3

APOA-IQ3

CETPQ3

Abstract

Background and objectives: Atherosclerosis results from a complex interaction between genetic and environmental factors. Free cholesterol efflux from peripheral tissues and transferring to the liver for excretion from bile which is known as reverse cholesterol transfer (RCT) plays a central role in protection against atherosclerosis. HDL and cholesteryl ester transfer protein (CETP) are the major participants of RCT. The aim of the present study was to investigate whether the cholesteryl ester transfer protein I405V polymorphism modifies the response to changes in the dietary ratio of polyunsaturated to saturated fat (P:S).Materials and Methods: The population study included 85 healthy subjects with the different I405V genotypes (35 II, 36 IV, and 14 VV) who assigned to two consecutive 28 days experimental period. All subjects consumed a high polyunsaturated fatty acids (PUFA) diet with P:S of 1.2 for the first period and a high saturated fatty acids (SFA) diet with a P:S of 0.3 for the next 28 days period. At the first and the end of each dietary period, serum lipid and lipoprotein concentrations were measured.Results: At beginning of screening, lipid or lipoprotein concentrations were not significantly different among CETP I405V genotype groups. After the high SFA diet, subjects carrying V allele had a greater reduction in apolipoprotein A-I (apoA-I) and HDL cholesterol (HDL-C) than subjects with II genotype.Conclusion: The CETP I405V polymorphism contributes to the unfavorable changes of apoA- I and HDL-C when a high PUFA diet were replaced with a high SFA diet.

Cites

No record.

References

No record.

Cite

APA: Copy

DARABI, MASOUD, ABOU ALFATHI, A.A., OSTAD RAHIMI, A.R., KAZEMI, ABD ALHASAN, SHAKER, M., & NOURI, MOHAMMAD. (2010). EFFECT OF THE CHOLESTERYL ESTER TRANSFER PROTEIN I405V POLYMORPHISM ON THE LIPID RESPONSE TO CHANGES OF DIETARY FATTY ACID COMPOSITION. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 17(69), 54-61. SID. https://sid.ir/paper/61436/en

Vancouver: Copy

DARABI MASOUD, ABOU ALFATHI A.A., OSTAD RAHIMI A.R., KAZEMI ABD ALHASAN, SHAKER M., NOURI MOHAMMAD. EFFECT OF THE CHOLESTERYL ESTER TRANSFER PROTEIN I405V POLYMORPHISM ON THE LIPID RESPONSE TO CHANGES OF DIETARY FATTY ACID COMPOSITION. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2010;17(69):54-61. Available from: https://sid.ir/paper/61436/en

IEEE: Copy

MASOUD DARABI, A.A. ABOU ALFATHI, A.R. OSTAD RAHIMI, ABD ALHASAN KAZEMI, M. SHAKER, and MOHAMMAD NOURI, “EFFECT OF THE CHOLESTERYL ESTER TRANSFER PROTEIN I405V POLYMORPHISM ON THE LIPID RESPONSE TO CHANGES OF DIETARY FATTY ACID COMPOSITION,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 17, no. 69, pp. 54–61, 2010, [Online]. Available: https://sid.ir/paper/61436/en

Related Journal Papers