THE COMPARISON EFFECTS OF ANALGESICS FLUNIXIN MEGLUMINE AND KETOPROFEN IN PAIN INDUCED BY PEROXYNITRITE IN GUINEA-PIGS

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MOGHADAMI I.; ILKHANIPOUR M.; SADEGHI HASHJIN G.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2010 | Volume:17 | Issue:69 Page(s): 1-12

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Title

THE COMPARISON EFFECTS OF ANALGESICS FLUNIXIN MEGLUMINE AND KETOPROFEN IN PAIN INDUCED BY PEROXYNITRITE IN GUINEA-PIGS

Author(s)

MOGHADAMI I. | ILKHANIPOUR M. | SADEGHI HASHJIN G. | Issue Writer Certificate

Keywords

INFLAMMATIONQ2

PAINQ2

FLUNIXIN MEGLUMINEQ3

KETOPROFENQ3

PEROXYNITRITEQ3

Abstract

Background and objectives: Non steroidal anti inflammatory drugs (NSAIDs) are widely used to reduce INFLAMMATION, PAIN and fever. The present study was organized to induce an experimental INFLAMMATION in an animal model, using a putative biological oxidant, PEROXYNITRITE (ONOO-) and to study the effects of FLUNIXIN MEGLUMINE and KETOPROFEN on the pressure-induced PAIN.Materials and Methods: For this purpose, 24 male guinea pigs were divided into 4 groups each consisting of 6 animals. Three groups (groups 2, 3 and 4) were injected PEROXYNITRITE and one group (the first: control) received physiological salt solution subcutaneously in the paw. After induction of a local inflammatory response, FLUNIXIN MEGLUMINE (1mg/kg) and KETOPROFEN (2 mg/kg) were injected to the second and third groups, 5 times with 12h intervals. The first and the fourth groups were injected saline solution in the same manner. Pressure analgesiometry was performed before and 1 hour after injections. Result: The animals in all 3 groups treated with PEROXYNITRITE demonstrated an increased sensitivity to PAINful pressure (P<0.05). Both NSAIDs decreased the PAIN sensation dramatically after the 1st and the 2nd injections but, not after the 3rd, 4th and the 5th injections.Conclusion: The study suggested that NSAIDs may be helpful in reducing pressure-induced PAIN in animal model in early hours of the treatment, whereas the effect subsides over time and ends up after a few days. This effect may be of importance in humans who receive these kinds of drugs for a long period as they may not be effective in reducing PAIN after a while.

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APA: Copy

MOGHADAMI, I., ILKHANIPOUR, M., & SADEGHI HASHJIN, G.. (2010). THE COMPARISON EFFECTS OF ANALGESICS FLUNIXIN MEGLUMINE AND KETOPROFEN IN PAIN INDUCED BY PEROXYNITRITE IN GUINEA-PIGS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 17(69), 1-12. SID. https://sid.ir/paper/61437/en

Vancouver: Copy

MOGHADAMI I., ILKHANIPOUR M., SADEGHI HASHJIN G.. THE COMPARISON EFFECTS OF ANALGESICS FLUNIXIN MEGLUMINE AND KETOPROFEN IN PAIN INDUCED BY PEROXYNITRITE IN GUINEA-PIGS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2010;17(69):1-12. Available from: https://sid.ir/paper/61437/en

IEEE: Copy

I. MOGHADAMI, M. ILKHANIPOUR, and G. SADEGHI HASHJIN, “THE COMPARISON EFFECTS OF ANALGESICS FLUNIXIN MEGLUMINE AND KETOPROFEN IN PAIN INDUCED BY PEROXYNITRITE IN GUINEA-PIGS,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 17, no. 69, pp. 1–12, 2010, [Online]. Available: https://sid.ir/paper/61437/en

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