EVALUATION OF MITOCHONDRIAL DNA HV1 REGION: AN APPROACH TO PERSONAL IDENTIFICATION VIA MATERNAL GENERATION

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MOROVATI S.; MODARESI MAHASTI

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Journal: JOURNAL OF MILITARY MEDICINE Year:2005 | Volume:7 | Issue:2 Page(s): 113-119

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Title

EVALUATION OF MITOCHONDRIAL DNA HV1 REGION: AN APPROACH TO PERSONAL IDENTIFICATION VIA MATERNAL GENERATION

Author(s)

MOROVATI S. | MODARESI MAHASTI | Issue Writer Certificate

Keywords

MITOCHONDRIAL DNAQ4

FORENSIC SCIENCEQ4

HV1Q4

D-LOOPQ4

POLYMORPHISMQ4

Abstract

Introduction: MITOCHONDRIAL DNA (mtDNA) sequence analysis of the hypervariable control region has been shown to be an effective tool for personal identification. The high copy, resistance to degradation, short size (as compared with nuclear DNA) and maternal mode of inheritance make mtDNA analysis particularly useful when old age or degradation of biological sample prohibits the detection and analysis of nuclear DNA. Material and Method: This study reports mtDNA POLYMORPHISMs in HV1 of the non coding D-LOOP region from 30 persons (10 unrelated families in 3 sequential maternal generations). Results: 32 polymorphic nucleotide positions were found in this region. The sequence of HV1 and its POLYMORPHISM were completely similar in each family. The average number of nucleotide differences between families in this region was 5.2 nucleotides. Discussion: We will expect approximately 5 nucleotide differences in HV1 sequence in two unknown, unrelated samples and no difference in maternal related samples. This method specially can be used for identification of war victims.

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APA: Copy

MOROVATI, S., & MODARESI, MAHASTI. (2005). EVALUATION OF MITOCHONDRIAL DNA HV1 REGION: AN APPROACH TO PERSONAL IDENTIFICATION VIA MATERNAL GENERATION. JOURNAL OF MILITARY MEDICINE, 7(2), 113-119. SID. https://sid.ir/paper/61866/en

Vancouver: Copy

MOROVATI S., MODARESI MAHASTI. EVALUATION OF MITOCHONDRIAL DNA HV1 REGION: AN APPROACH TO PERSONAL IDENTIFICATION VIA MATERNAL GENERATION. JOURNAL OF MILITARY MEDICINE[Internet]. 2005;7(2):113-119. Available from: https://sid.ir/paper/61866/en

IEEE: Copy

S. MOROVATI, and MAHASTI MODARESI, “EVALUATION OF MITOCHONDRIAL DNA HV1 REGION: AN APPROACH TO PERSONAL IDENTIFICATION VIA MATERNAL GENERATION,” JOURNAL OF MILITARY MEDICINE, vol. 7, no. 2, pp. 113–119, 2005, [Online]. Available: https://sid.ir/paper/61866/en

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