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Information Journal Paper

Title

PROTECTIVE EFFECTS OF VACCINIUM ARCTOSTAPHYLOS L., BERBERIS THUNBERGII VAR. ATROPURPUREA CHENAULT, ELAEAGNUS ANGUSTIFOLIA L. AND LAUNAEA ACANTHODES (BOISS.) O. KUNTZE AGAINST INDOMETHACIN-INDUCED GASTRIC ULCERS IN RATS

Pages

  62-69

Abstract

 Background: Data suggest that V. arctostaphylos, B. thunbergii var. atropurpurea, E. angustifolia and L. acanthodes may prevent gastric ulcers induced by Non-steroidal anti-inflammatory drugs (NSAIDs).Objective: To explore the ulcer-protective potential of these plants in indomethacin-induced gastric ulcers in RATs.Methods: Saline, hydro-alcoholic extract of each plant (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg, p.o.). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg, p.o.) or omeprazole (30 mg/kg, p.o.) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index.Results: All extracts reduced the ulcer index significantly compared to the control group (p<0.05).Conclusion: These plants prevent NSAID-induced gastric ulcers in RATs. The efficacy and potency of the gastro-protective effect of L. acanthodes appears to be higher than the other 3 plants.

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    APA: Copy

    FALLAH HUSEINI, H., KIANBAKHT, S., & HOORMAND, M.. (2013). PROTECTIVE EFFECTS OF VACCINIUM ARCTOSTAPHYLOS L., BERBERIS THUNBERGII VAR. ATROPURPUREA CHENAULT, ELAEAGNUS ANGUSTIFOLIA L. AND LAUNAEA ACANTHODES (BOISS.) O. KUNTZE AGAINST INDOMETHACIN-INDUCED GASTRIC ULCERS IN RATS. JOURNAL OF MEDICINAL PLANTS, 12(47), 62-69. SID. https://sid.ir/paper/619467/en

    Vancouver: Copy

    FALLAH HUSEINI H., KIANBAKHT S., HOORMAND M.. PROTECTIVE EFFECTS OF VACCINIUM ARCTOSTAPHYLOS L., BERBERIS THUNBERGII VAR. ATROPURPUREA CHENAULT, ELAEAGNUS ANGUSTIFOLIA L. AND LAUNAEA ACANTHODES (BOISS.) O. KUNTZE AGAINST INDOMETHACIN-INDUCED GASTRIC ULCERS IN RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2013;12(47):62-69. Available from: https://sid.ir/paper/619467/en

    IEEE: Copy

    H. FALLAH HUSEINI, S. KIANBAKHT, and M. HOORMAND, “PROTECTIVE EFFECTS OF VACCINIUM ARCTOSTAPHYLOS L., BERBERIS THUNBERGII VAR. ATROPURPUREA CHENAULT, ELAEAGNUS ANGUSTIFOLIA L. AND LAUNAEA ACANTHODES (BOISS.) O. KUNTZE AGAINST INDOMETHACIN-INDUCED GASTRIC ULCERS IN RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 12, no. 47, pp. 62–69, 2013, [Online]. Available: https://sid.ir/paper/619467/en

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