THE ROLE OF REACTIVE OXYGEN SPECIES IN DELAYED OPHTHALMIC DISORDERS OF SULFUR MUSTARD

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JADIDI KH.; ALAVI S.A.A.F.; HADIZADEH F.; MIRKHESHTI NOUSHIN; GHASAMI F.; TALEBI SH.; SOLEIMANI Z.

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Journal: JOURNAL OF MILITARY MEDICINE Year:2005 | Volume:7 | Issue:1 Page(s): 9-14

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Title

THE ROLE OF REACTIVE OXYGEN SPECIES IN DELAYED OPHTHALMIC DISORDERS OF SULFUR MUSTARD

Author(s)

Keywords

SULFUR MUSTARDQ3

EYEQ4

COMPLICATIONQ3

REACTIVE OXYGEN SPECIESQ4

Abstract

Introduction: Delayed ophthalmic disorders of mustard gas which may lead to blindness are important COMPLICATIONs. In only 0.5 percent of cases, severe disorders result from high doses of mustard, but problems such as the dry EYE are prevalent. In order to study the involvement of the oxidant/antioxidant systems in the pathophysiology of such COMPLICATIONs, this research analyzed hydrogen peroxide, the main inducer of hydroxyl radical in the EYE; and defensive properties both against the most important ocular oxidant, i.e. superoxide radical, and against the most potent ophthalmic radical, namely hydroxyl radical, in the serum and tear of patients.Materials and Methods: Hydrogen peroxide was determined in tear and serum by the FOX1 method as expounded by Wolff. The Halliwell method and Rook method were employed in order to estimate hydroxyl radical scavengering properties of serum and superoxide radical scavengering of tear and serum, respectively.Results: A significant difference between hydrogen peroxide values in the serum of the cases and controls (P value<0.001) was observed. There were no other significant difference in other measurements.Discussion: A hypothesis can be induced from the results: Because of the other delayed disorders of mustard injury, such as the pulmonary COMPLICATIONs, hydrogen peroxide is released in the blood from different sources. But protection against important free radicals such as superoxide and hydroxyl radicals does not increase. Therefore, problems such as the dry EYE and keratopathies occur.

Cites

EFFECT OF LONG–TERM PULMONARY COMPLICATIONS DUE TO SULFUR MUSTARD ON ACTIVATION OF ENZYMES IN ANTIOXIDANT SYSTEM

References

بررسی عوارض چشمی گاز خردل در مجروحین شیمیایی جنگ تحمیلی

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APA: Copy

JADIDI, KH., ALAVI, S.A.A.F., HADIZADEH, F., MIRKHESHTI, NOUSHIN, GHASAMI, F., TALEBI, SH., & SOLEIMANI, Z.. (2005). THE ROLE OF REACTIVE OXYGEN SPECIES IN DELAYED OPHTHALMIC DISORDERS OF SULFUR MUSTARD. JOURNAL OF MILITARY MEDICINE, 7(1), 9-14. SID. https://sid.ir/paper/62016/en

Vancouver: Copy

JADIDI KH., ALAVI S.A.A.F., HADIZADEH F., MIRKHESHTI NOUSHIN, GHASAMI F., TALEBI SH., SOLEIMANI Z.. THE ROLE OF REACTIVE OXYGEN SPECIES IN DELAYED OPHTHALMIC DISORDERS OF SULFUR MUSTARD. JOURNAL OF MILITARY MEDICINE[Internet]. 2005;7(1):9-14. Available from: https://sid.ir/paper/62016/en

IEEE: Copy

KH. JADIDI, S.A.A.F. ALAVI, F. HADIZADEH, NOUSHIN MIRKHESHTI, F. GHASAMI, SH. TALEBI, and Z. SOLEIMANI, “THE ROLE OF REACTIVE OXYGEN SPECIES IN DELAYED OPHTHALMIC DISORDERS OF SULFUR MUSTARD,” JOURNAL OF MILITARY MEDICINE, vol. 7, no. 1, pp. 9–14, 2005, [Online]. Available: https://sid.ir/paper/62016/en

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