SUPERFUSION TECHNIQUE FOR STUDYING MECHANISMS OF CNS COMPLICATIONS IN ORGANOPHOSPHATE TOXICITY

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HOSSEINI SEYED MEHRAN; ASGARI A.; MEHRANI H.A.; POURABD ALHOSSEINI F.; SHAHROKHI A.; KHOUSHBATEN A.

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Journal: Journal of Military Medicine Year:2005 | Volume:7 | Issue:1 Page(s): 15-20

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Title

SUPERFUSION TECHNIQUE FOR STUDYING MECHANISMS OF CNS COMPLICATIONS IN ORGANOPHOSPHATE TOXICITY

Author(s)

Keywords

SUPERFUSIONQ4

SYNAPTOSOMEQ4

ORGANOPHOSPHATEQ2

CEREBELLUMQ4

Abstract

Introduction: ORGANOPHOSPHATE poisoning produces nicotinic and muscarinic effects in both peripheral and central nervous systems. In an attempt for a better management of victims, non-cholinergic mechanisms are also investigated. ORGANOPHOSPHATE compounds can affect many structural elements of chemical synapses; there is also a complex interaction between the cholinergic system and other neurotransmitters in the brain. SUPERFUSION of rat cerebellar SYNAPTOSOMEs may be an appropriate approach to study the pathogenesis of central complications of ORGANOPHOSPHATE toxicity.Methods: The present study was conducted in three stages: preparing cerebellar SYNAPTOSOMEs, calibrating the SUPERFUSION system set-up and testing the release of labled GABA from SYNAPTOSOMEs.Results: The outflow of [3H]GABA from superfused SYNAPTOSOMEs nearly showed a linear kinetic. The K+-evoked depolarization caused 2-3 fold increases upon basal spontaneous release.Discussion: It seems that cerebellar SYNAPTOSOME SUPERFUSION may be used as an appropriate in vitro approach to study the mechanisms of ORGANOPHOSPHATEs central complications. Regarding the spontaneous or stimulated release, differential assessments and different tests can be simultaneously carried out on the same samples.

Cites

THE PREPARATION OF RAT CEREBELLAR SYNAPTOSOME AND ITS APPLICATIONS IN STUDYING PRESYNAPTIC MEBRANE PROTEINS: BRIEF REPORT

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APA: Copy

HOSSEINI, SEYED MEHRAN, ASGARI, A., MEHRANI, H.A., POURABD ALHOSSEINI, F., SHAHROKHI, A., & KHOUSHBATEN, A.. (2005). SUPERFUSION TECHNIQUE FOR STUDYING MECHANISMS OF CNS COMPLICATIONS IN ORGANOPHOSPHATE TOXICITY. JOURNAL OF MILITARY MEDICINE, 7(1), 15-20. SID. https://sid.ir/paper/62017/en

Vancouver: Copy

HOSSEINI SEYED MEHRAN, ASGARI A., MEHRANI H.A., POURABD ALHOSSEINI F., SHAHROKHI A., KHOUSHBATEN A.. SUPERFUSION TECHNIQUE FOR STUDYING MECHANISMS OF CNS COMPLICATIONS IN ORGANOPHOSPHATE TOXICITY. JOURNAL OF MILITARY MEDICINE[Internet]. 2005;7(1):15-20. Available from: https://sid.ir/paper/62017/en

IEEE: Copy

SEYED MEHRAN HOSSEINI, A. ASGARI, H.A. MEHRANI, F. POURABD ALHOSSEINI, A. SHAHROKHI, and A. KHOUSHBATEN, “SUPERFUSION TECHNIQUE FOR STUDYING MECHANISMS OF CNS COMPLICATIONS IN ORGANOPHOSPHATE TOXICITY,” JOURNAL OF MILITARY MEDICINE, vol. 7, no. 1, pp. 15–20, 2005, [Online]. Available: https://sid.ir/paper/62017/en

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