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Title

FLUOXETIN UPREGULATES CONNEXIN 43 EXPRESSION IN ASTROCYTE

Pages

  74-79

Abstract

 Introduction: Recent studies have shown that ASTROCYTEs play major roles in normal and disease condition of the central nervous system including multiple sclerosis (MS). Molecular target therapy studies in MS have revealed that CONNEXIN-43 (Cx43) and AQUAPORIN-4 (AQP4) contents of ASTROCYTEs undergo expression alteration. FLUOXETINE had some effects in MS patients unrelated to its known antidepressant effects. Some of FLUOXETINE effects were attributed to its capability of CAMP signaling pathway stimulation. This study aimed to investigate possible acute effects of FLUOXETINE on Cx43 and AQP4 expression in ASTROCYTE.Methods: Astrocytoma cells were treated for 24 hours with FLUOXETINE (10 and 20 mg/ml) with or without adenyl cyclase (AC) and protein kinase A (PKA) inhibition. Cx43 expression at both mRNA and protein levels and AQP4 expression at mRNA level were evaluated.Results: Acquired results showed that FLUOXETINE with and without AC and PKA inhibition resulted in Cx43 up-regulation both in mRNA and protein levels, whereas AQP4 expression have not changed.Discussion: In conclusion, data showed that FLUOXETINE alone and in the absence of serotonin acutely up-regulated Cx43 expression in ASTROCYTEs that can be assumed in molecular target therapy of MS patients. It seems that CAMP involvement in FLUOXETINE effects need more researches.

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    APA: Copy

    MOSTAFAVI, HOSSEIN, KHAKSARIAN, MOJTABA, JOGHATAEI, MOHAMMAD TAGHI, HASSANZADEH, GHOLAMREZA, SOLEIMANI, MASOUD, EFTEKHARI, SANAZ, SOLEIMANI, MANSOOREH, MOUSAVIZADEH, KAZEM, & HADJIGHASSEM, MAHMOUD REZA. (2014). FLUOXETIN UPREGULATES CONNEXIN 43 EXPRESSION IN ASTROCYTE. VIRTUAL, 5(1), 74-79. SID. https://sid.ir/paper/624149/en

    Vancouver: Copy

    MOSTAFAVI HOSSEIN, KHAKSARIAN MOJTABA, JOGHATAEI MOHAMMAD TAGHI, HASSANZADEH GHOLAMREZA, SOLEIMANI MASOUD, EFTEKHARI SANAZ, SOLEIMANI MANSOOREH, MOUSAVIZADEH KAZEM, HADJIGHASSEM MAHMOUD REZA. FLUOXETIN UPREGULATES CONNEXIN 43 EXPRESSION IN ASTROCYTE. VIRTUAL[Internet]. 2014;5(1):74-79. Available from: https://sid.ir/paper/624149/en

    IEEE: Copy

    HOSSEIN MOSTAFAVI, MOJTABA KHAKSARIAN, MOHAMMAD TAGHI JOGHATAEI, GHOLAMREZA HASSANZADEH, MASOUD SOLEIMANI, SANAZ EFTEKHARI, MANSOOREH SOLEIMANI, KAZEM MOUSAVIZADEH, and MAHMOUD REZA HADJIGHASSEM, “FLUOXETIN UPREGULATES CONNEXIN 43 EXPRESSION IN ASTROCYTE,” VIRTUAL, vol. 5, no. 1, pp. 74–79, 2014, [Online]. Available: https://sid.ir/paper/624149/en

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