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Information Journal Paper

Title

PULMONARY COMPLICATIONS OF GASTRIC FLUID AND BILE SALTS ASPIRATION, AN EXPERIMENTAL STUDY IN RAT

Pages

  790-796

Abstract

 Objective(s): GASTROESOPHAGEAL REFLUX Disease (GERD) is one of the most common digestive disorders that frequently lead to pulmonary complications due to GASTRIC FLUID aspiration. In the present experimental study, chronic aspiration of GASTRIC FLUID, its components and BILE SALTS in rat lung was performed to find out the main factor(s) causing pulmonary complications of GASTRIC FLUID aspiration.Materials and Methods: Forty eight male rats weighted 250-300 g were selected in six groups. After anesthesia and tracheal cannulation, the animals received 0.5 ml/kg normal saline, 0.5 ml/kg of whole GASTRIC FLUID, 0.5 ml/kg pepsin (2.5 mg/ml), 0.5 ml/kg hydrochloric acid (pH=1.5) or 0.5 ml/kg BILE SALTS (2.5 mg/ml) by injection into their trachea and lungs. In sham group nothing was injected.Results: Parenchymal and airways inflammation and fibrosis of bronchi, bronchioles and parenchyma were significantly more in the test groups compared to saline and sham groups (P<0.001); also inflammation in pepsin and BILE SALTS groups (histopathology scores: 2.87±0.35 and 3.0±0.0 for bronchial, 2.87±0.35 and 2.87±0.35 for bronchioles, 2.87±0.35 and 2.87±0.35 for parenchymal inflammation) were more than hydrochloric acid and GASTRIC FLUID groups (1.75±0.46 and 2.5±0.53 for bronchial, 2.0±0.0 and 2.0±0.0 for bronchioles, 2.0±0.0 and 2.0±0.0 for parenchymal inflammation) (P<0.05). The same results were found for fibrosis, so that the fibrosis in pepsin and BILE SALTS groups were more than hydrochloric acid and GASTRIC FLUID groups (P<0.05).Conclusion: The present results suggested that pulmonary complications causing from BILE SALTS and pepsin might be more than gastric juice and hydrochloric acid.

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    • Cite

    APA: Copy

    SAMAREH FEKRI, MITRA, POURSALEHI, HAMID REZA, NAJAFIPOUR, HAMID, DABIRI, SHAHRIAR, SHOKOOHI, MOSTAFA, SIAHPOSHT KHACHEKI, ALI, SHAHROKHI, NADER, MALEKPOUR AFSHAR, REZA, & LASHKARIZADEH, MOHAMMAD REZA. (2013). PULMONARY COMPLICATIONS OF GASTRIC FLUID AND BILE SALTS ASPIRATION, AN EXPERIMENTAL STUDY IN RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(6), 790-796. SID. https://sid.ir/paper/627868/en

    Vancouver: Copy

    SAMAREH FEKRI MITRA, POURSALEHI HAMID REZA, NAJAFIPOUR HAMID, DABIRI SHAHRIAR, SHOKOOHI MOSTAFA, SIAHPOSHT KHACHEKI ALI, SHAHROKHI NADER, MALEKPOUR AFSHAR REZA, LASHKARIZADEH MOHAMMAD REZA. PULMONARY COMPLICATIONS OF GASTRIC FLUID AND BILE SALTS ASPIRATION, AN EXPERIMENTAL STUDY IN RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(6):790-796. Available from: https://sid.ir/paper/627868/en

    IEEE: Copy

    MITRA SAMAREH FEKRI, HAMID REZA POURSALEHI, HAMID NAJAFIPOUR, SHAHRIAR DABIRI, MOSTAFA SHOKOOHI, ALI SIAHPOSHT KHACHEKI, NADER SHAHROKHI, REZA MALEKPOUR AFSHAR, and MOHAMMAD REZA LASHKARIZADEH, “PULMONARY COMPLICATIONS OF GASTRIC FLUID AND BILE SALTS ASPIRATION, AN EXPERIMENTAL STUDY IN RAT,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 6, pp. 790–796, 2013, [Online]. Available: https://sid.ir/paper/627868/en

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