مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

STUDY THE ANTINOCICEPTIVE EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF AQUEOUS EXTRACT OF ORIGANUM VULGARE LEAVES IN RAT: POSSIBLE INVOLVEMENT OF OPIOID SYSTEM

Pages

  1109-1113

Abstract

 Objective (s): The aim of study was to investigate the antinociceptive effect of INTRACEREBROVENTRICULAR (ICV) microinjection of ORIGANUM VULGARE (ORG) extract and possible involvement of opioid receptors.Materials and Methods: Cannula was inserted into left ventricle of male RATs. Five days after surgery Tail Flick Latency (TFL) was measured after ICV microinjection of, ORG (1, 3 and 6 mg / RAT). Effective dose of ORG was injected ICV in concomitant with morphine (2 mg/kg, IP), naloxone (2 mg / kg, IP) and saline (0.5 ml/rat) and TFL was recorded.Results: The co- administration of ORG extract with morphine showed a significant increase in TFL and naloxone, pretreatment significantly inhibited the antinociceptive activity of ORG and morphine.Conclusion: The aqueous extract of ORG possesses antinociceptive activities in the TAIL-FLICK TEST in a dose dependent manner. ORG - induced antinociception may have been mediated by opioid systems.

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    • Cite

    APA: Copy

    PAHLAVAN, YASAMAN, SEPEHRI, GHOLAMREZA, SHEIBANI, VAHID, AFARINESHE KHAKI, MOHAMMAD REZA, GOJAZADEH, MORTEZA, PAHLAVAN, BAHARE, & PAHLAVAN, FERESHTEH. (2013). STUDY THE ANTINOCICEPTIVE EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF AQUEOUS EXTRACT OF ORIGANUM VULGARE LEAVES IN RAT: POSSIBLE INVOLVEMENT OF OPIOID SYSTEM. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(10), 1109-1113. SID. https://sid.ir/paper/629405/en

    Vancouver: Copy

    PAHLAVAN YASAMAN, SEPEHRI GHOLAMREZA, SHEIBANI VAHID, AFARINESHE KHAKI MOHAMMAD REZA, GOJAZADEH MORTEZA, PAHLAVAN BAHARE, PAHLAVAN FERESHTEH. STUDY THE ANTINOCICEPTIVE EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF AQUEOUS EXTRACT OF ORIGANUM VULGARE LEAVES IN RAT: POSSIBLE INVOLVEMENT OF OPIOID SYSTEM. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(10):1109-1113. Available from: https://sid.ir/paper/629405/en

    IEEE: Copy

    YASAMAN PAHLAVAN, GHOLAMREZA SEPEHRI, VAHID SHEIBANI, MOHAMMAD REZA AFARINESHE KHAKI, MORTEZA GOJAZADEH, BAHARE PAHLAVAN, and FERESHTEH PAHLAVAN, “STUDY THE ANTINOCICEPTIVE EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF AQUEOUS EXTRACT OF ORIGANUM VULGARE LEAVES IN RAT: POSSIBLE INVOLVEMENT OF OPIOID SYSTEM,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 10, pp. 1109–1113, 2013, [Online]. Available: https://sid.ir/paper/629405/en

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