Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

327
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

226
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

SYNTHESIS AND EVALUATION OF ANTI-ACETYLCHOLINESTERASE ACTIVITY OF 2- (2- (4- (2-OXO-2-PHENYLETHYL) PIPERAZIN-1-YL) ETHYL) ISOINDOLINE-1, 3-DIONE DERIVATIVES WITH POTENTIAL ANTI-ALZHEIMER EFFECTS

Pages

  1049-1054

Abstract

 Objective (s): Alzheimer's disease (AD) is a neurodegenerative disorder in elderly patients. Decrease in cholinergic neurotransmission is the main known cause in the pathophysiology of the disease. Improvement and potentiation of the cholinergic system could be beneficial for treatment of the AD. Acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylcholine (Ach) and therefore, through this mechanism improve the symptoms of AD. Materials and Methods: In the current study, based on the potential inhibitory activity of phthalimide derivatives towards acetylcholinesterase enzyme, a new series of phthalimide-based compounds were synthesized (4a-4e) and anti-acetylcholinesterase effect was assessed using Ellman’s test. Compound 4b with 4-Fluorophenyl moiety was the most potent derivative in this series (IC50=16.42±1.07 mM). It was shown that, none of the synthesized compounds showed superior inhibitory potency compared to donepezil (0.41±0.09 mM) as a reference drug.Conclusion: The new synthesized phthalimide based analogs could function as potential acetylcholinesterase inhibitors. Further studies are necessary for development of potent analogs.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    ALIABADI, ALIREZA, FOROUMADI, ALIREZA, MOHAMMADI FARANI, AHMAD, & GARMSIRI MAHVAR, MAHDI. (2013). SYNTHESIS AND EVALUATION OF ANTI-ACETYLCHOLINESTERASE ACTIVITY OF 2- (2- (4- (2-OXO-2-PHENYLETHYL) PIPERAZIN-1-YL) ETHYL) ISOINDOLINE-1, 3-DIONE DERIVATIVES WITH POTENTIAL ANTI-ALZHEIMER EFFECTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(10), 1049-1054. SID. https://sid.ir/paper/629673/en

    Vancouver: Copy

    ALIABADI ALIREZA, FOROUMADI ALIREZA, MOHAMMADI FARANI AHMAD, GARMSIRI MAHVAR MAHDI. SYNTHESIS AND EVALUATION OF ANTI-ACETYLCHOLINESTERASE ACTIVITY OF 2- (2- (4- (2-OXO-2-PHENYLETHYL) PIPERAZIN-1-YL) ETHYL) ISOINDOLINE-1, 3-DIONE DERIVATIVES WITH POTENTIAL ANTI-ALZHEIMER EFFECTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(10):1049-1054. Available from: https://sid.ir/paper/629673/en

    IEEE: Copy

    ALIREZA ALIABADI, ALIREZA FOROUMADI, AHMAD MOHAMMADI FARANI, and MAHDI GARMSIRI MAHVAR, “SYNTHESIS AND EVALUATION OF ANTI-ACETYLCHOLINESTERASE ACTIVITY OF 2- (2- (4- (2-OXO-2-PHENYLETHYL) PIPERAZIN-1-YL) ETHYL) ISOINDOLINE-1, 3-DIONE DERIVATIVES WITH POTENTIAL ANTI-ALZHEIMER EFFECTS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 10, pp. 1049–1054, 2013, [Online]. Available: https://sid.ir/paper/629673/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top