EVALUATION OF EFFECTS OF EPINEPHRINE PLUS TO ANALGESIC EFFECTS OF BUPIVACAINE AND SUFENTANIL IN LABOR ANALGESIA

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FARAHZADI R.; GHADIANI S.; DABAGH ALI; KHORASANI SH.; RAMBOUD M.

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Paper Information

Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2004 | Volume:25 | Issue:47 Page(s): 65-71

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Title

EVALUATION OF EFFECTS OF EPINEPHRINE PLUS TO ANALGESIC EFFECTS OF BUPIVACAINE AND SUFENTANIL IN LABOR ANALGESIA

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Keywords

LABORQ3

ANALGESIAQ3

INTRATHECAL EPINEPHRINEQ4

Abstract

Fear of LABOR pain is a leading cause which increases the trend of elective cesarean deliveries, so it is mandatory to change this trend by a number of interventions. Spinal ANALGESIA could be an effective method for this purpose. This study was designed and execurted to assess the effectiveness of epinephrine added to intrathecal bupivacaine + sufentanil in alleviating the LABOR pain. In a randomized clinical trial, 39 parturient women in their second LABOR, who had their first experience of LABOR painfully, were allocated in 2 groups randomly: the first group received intrathecal bupivacain (2.5 mg) + sufentanil (5 mcg) and the second group received the same regimen with 0.2 mg epinephrine. Total ANALGESIA time, FHR trend, nausea, pruritus, SpO2 trend, patient's respiratory status and blood pressure changes were monitored to see the possible differences. Student t-test and Chi-square test were used to analyze part of the results and p-value<0.05 was considered significant. The results did not suggest any significant statistical difference between the 2 groups regarding the aforementioned criteria. This study could not prove epinephrine as an effective adjunct for the intrathecal bupivacaine + sufentanil in alleviating the LABOR pain, and at the same time, due to possible epinephrine hazards in the parturient, discourages its usage in LABOR ANALGESIA.

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