EFFECT OF DEXMEDETOMIDINE INFUSION ON N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE LEVEL IN PATIENTS WITH FEMORAL SHAFT FRACTURES UNDER GENERAL ANESTHESIA

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MIRKHESHTI ALIREZA; MEMARY ELHAM; SHAFIEE HAMED; DAHI MASTANEH

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2015 | Volume:37 | Issue:4 (92) Page(s): 0-0

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Title

EFFECT OF DEXMEDETOMIDINE INFUSION ON N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE LEVEL IN PATIENTS WITH FEMORAL SHAFT FRACTURES UNDER GENERAL ANESTHESIA

Author(s)

MIRKHESHTI ALIREZA | MEMARY ELHAM | SHAFIEE HAMED | DAHI MASTANEH | Issue Writer Certificate

Keywords

DEXMEDETOMIDINEQ3

FEMORAL SHAFT FRACTURESQ3

GENERAL ANESTHESIAQ2

Abstract

Background: Control of hemodynamic parameters and decrease blood loss in major orthopedic procedures are of great anesthetic concerns which can reduce perioperative cardiovascular complications and moreover decrease the incidence of blood transfusion and consequently the related complications such as hemolysis, infection, non hemolytic reaction and pulmonary side effects. The aim of our study is to determine dexmedtomidine effects on hemodynamic parameters and blood loss in patients under femoral shaft fracture surgeries.Objectives: We aimed to determine the effects of DEXMEDETOMIDINE on NT pro BNP levels and hemodynamic parameters of patients under femoral shaft fracture surgeries.Materials and Methods: In a clinical trial study, 50 patients between 15 to 65 years, ASA class I, II undergoing GENERAL ANESTHESIA for surgery of femoral shaft fracture were assessed. Protocol of GENERAL ANESTHESIA and postoperative pain control for all patients was the same. In DEXMEDETOMIDINE group, 0.5 μg/kg/hr of DEXMEDETOMIDINE was infused during the time of operation and in control group, 0.9 sodium chloride by the same manner of case group was infused.Results: Trend of the change in systolic and diastolic blood pressure was statistically significant different between two groups (P<0.001). A significant decrease of pulse rate during the surgery was detected (P<0.001) but the trend of change in pulse rate was not statistically significant (P=0.055). Blood loss in DEXMEDETOMIDINE group was significantly less than control one (p<0.001).Conclusions: systolic and diastolic blood pressures are better controlled during infusion of DEXMEDETOMIDINE and also it can decrease the amount of bleeding in femoral shaft fracture surgeries.

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APA: Copy

MIRKHESHTI, ALIREZA, MEMARY, ELHAM, SHAFIEE, HAMED, & DAHI, MASTANEH. (2015). EFFECT OF DEXMEDETOMIDINE INFUSION ON N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE LEVEL IN PATIENTS WITH FEMORAL SHAFT FRACTURES UNDER GENERAL ANESTHESIA. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 37(4 (92) ), 0-0. SID. https://sid.ir/paper/63474/en

Vancouver: Copy

MIRKHESHTI ALIREZA, MEMARY ELHAM, SHAFIEE HAMED, DAHI MASTANEH. EFFECT OF DEXMEDETOMIDINE INFUSION ON N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE LEVEL IN PATIENTS WITH FEMORAL SHAFT FRACTURES UNDER GENERAL ANESTHESIA. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2015;37(4 (92) ):0-0. Available from: https://sid.ir/paper/63474/en

IEEE: Copy

ALIREZA MIRKHESHTI, ELHAM MEMARY, HAMED SHAFIEE, and MASTANEH DAHI, “EFFECT OF DEXMEDETOMIDINE INFUSION ON N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE LEVEL IN PATIENTS WITH FEMORAL SHAFT FRACTURES UNDER GENERAL ANESTHESIA,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 37, no. 4 (92) , pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/63474/en

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