THE EFFECT OF ORAL DESMOPRESSIN IN PATIENTS WITH NOCTURIA DUE TO BENIGN PROSTATIC HYPERPLASIA: SHORT TERM AND LONG TERM RESULTS

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KESHVARI MALIHE; TAGHAVI RAHIM; SHAKIBA BEHNAM

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Journal: Studies in Medical Sciences Year:2010 | Volume:21 | Issue:3 Page(s): 221-227

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Title

THE EFFECT OF ORAL DESMOPRESSIN IN PATIENTS WITH NOCTURIA DUE TO BENIGN PROSTATIC HYPERPLASIA: SHORT TERM AND LONG TERM RESULTS

Author(s)

KESHVARI MALIHE | TAGHAVI RAHIM | SHAKIBA BEHNAM | Issue Writer Certificate

Keywords

DESMOPRESSINQ3

BENIGN PROSTATIC HYPERPLASIAQ3

NOCTURIAQ3

Abstract

Background and Aims: NOCTURIA is a common symptom of BENIGN PROSTATIC HYPERPLASIA (BPH). It may be treated with a blockers and 5 a reductase inhibitors, but in some patients, NOCTURIA remains. In this study we assessed the short term and long term effects of oral DESMOPRESSIN in patients with NOCTURIA due to BPH.Materials and Methods: Twenty three adult men with BPH and bothering NOCTURIA (³2voids/night) were treated with oral DESMOPRESSIN at bedtime. Exclusion criteria included active urinary tract infection, history of myocardial infarction, congestive heart failure, angina and hyponatremia. Patients received DESMOPRESSIN tablets (0.1, 0.2, or 0.4 mg) during a three week dose titration period and after one week washout period the effective drug dose continued for 1 year. Clinical responses in patients were evaluated after 6 to 8 weeks and 1 year.Results: All patients improved with this treatment. NOCTURIA episodes decreased from a mean of 4±0.36 episodes/night before treatment to1.17±0.28 episodes/night after treatment (P<0.0001). Hyponatremia did not occur in short term but in long term follow up, hyponatremia occurred in one patient.Conclusion: Oral DESMOPRESSIN tablets provide an effective and well tolerated treatment for NOCTURIA due to BPH.

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APA: Copy

KESHVARI, MALIHE, TAGHAVI, RAHIM, & SHAKIBA, BEHNAM. (2010). THE EFFECT OF ORAL DESMOPRESSIN IN PATIENTS WITH NOCTURIA DUE TO BENIGN PROSTATIC HYPERPLASIA: SHORT TERM AND LONG TERM RESULTS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 21(3), 221-227. SID. https://sid.ir/paper/63547/en

Vancouver: Copy

KESHVARI MALIHE, TAGHAVI RAHIM, SHAKIBA BEHNAM. THE EFFECT OF ORAL DESMOPRESSIN IN PATIENTS WITH NOCTURIA DUE TO BENIGN PROSTATIC HYPERPLASIA: SHORT TERM AND LONG TERM RESULTS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2010;21(3):221-227. Available from: https://sid.ir/paper/63547/en

IEEE: Copy

MALIHE KESHVARI, RAHIM TAGHAVI, and BEHNAM SHAKIBA, “THE EFFECT OF ORAL DESMOPRESSIN IN PATIENTS WITH NOCTURIA DUE TO BENIGN PROSTATIC HYPERPLASIA: SHORT TERM AND LONG TERM RESULTS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 21, no. 3, pp. 221–227, 2010, [Online]. Available: https://sid.ir/paper/63547/en

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