COMPARISON OF THREE AND TWO DRUGS INHIBITION OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) IN TREATMENT OF DIABETIC NEPHROPATHY

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NOSHAD HAMID

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Journal: Studies in Medical Sciences Year:2010 | Volume:21 | Issue:3 Page(s): 278-285

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Title

COMPARISON OF THREE AND TWO DRUGS INHIBITION OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) IN TREATMENT OF DIABETIC NEPHROPATHY

Author(s)

NOSHAD HAMID | Issue Writer Certificate

Keywords

DIABETIC NEPHROPATHYQ2

PROTEINURIAQ3

RENINQ3

ANGIOTENSINQ3

ALDOSTERONE SYSTEMQ3

Abstract

Background and Aims: According to the clinical guidelines on chronic kidney disease with hypertension, combination therapy with multiple RENIN-angiotensin-aldosterone system (RAAS) blockers have been recommended as standard first-line therapy. To date, dual and triple blockade of the RAAS has been evaluated. The aim of this study was comparing three (ACEI+ARB+b blocker) and two (ACEI+ARB) directional inhibitions of RAAS in treatment of DIABETIC NEPHROPATHY.Materials and Methods: In an experimental interventional study, 103 diabetic patients without ESRD were recruited in Tabriz Sina Hospital during a one-year period. The patients were randomized in two groups: group A received triple blockade of RAAS with ACEI+ARB+b blocker, and group B received dual blockade with ACEI+ARB (and placebo). Basal and post treatment parameters including blood pressure, urine albumin, serum BUN, Cr, Na, K, HbA1C, and GFR were compared.Results: Both study groups were matched for age, sex and duration of diabetes mellitus. Decrease of blood pressure, albuminuria, BUN, and Cr was more significant in group A compared with group B. The GFR rose more significantly in group A compared with group B. The frequency of hyperkalemia was significantly higher in group A.Conclusion: Triple blockade of RAAS is more efficient that dual blockade in prevention of DIABETIC NEPHROPATHY however, meticulous selection of patients should be considered because of higher risk of hyperkalemia.

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APA: Copy

NOSHAD, HAMID. (2010). COMPARISON OF THREE AND TWO DRUGS INHIBITION OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) IN TREATMENT OF DIABETIC NEPHROPATHY. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 21(3), 278-285. SID. https://sid.ir/paper/63551/en

Vancouver: Copy

NOSHAD HAMID. COMPARISON OF THREE AND TWO DRUGS INHIBITION OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) IN TREATMENT OF DIABETIC NEPHROPATHY. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2010;21(3):278-285. Available from: https://sid.ir/paper/63551/en

IEEE: Copy

HAMID NOSHAD, “COMPARISON OF THREE AND TWO DRUGS INHIBITION OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) IN TREATMENT OF DIABETIC NEPHROPATHY,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 21, no. 3, pp. 278–285, 2010, [Online]. Available: https://sid.ir/paper/63551/en

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