POLYMORPHISMS OF IFN-Γ AND IL-10 GENES IN NORMAL POPULATION

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ABDIRAD I.; BAGHERI M.; OMRANI M.D.; NOROUZI PAKZAD H.

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Journal: Studies in Medical Sciences Year:2010 | Volume:20 | Issue:4 Page(s): 307-312

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Title

POLYMORPHISMS OF IFN-Γ AND IL-10 GENES IN NORMAL POPULATION

Author(s)

ABDIRAD I. | BAGHERI M. | OMRANI M.D. | NOROUZI PAKZAD H. | Issue Writer Certificate

Keywords

POLYMORPHISMQ2

INTERFERON-γ+874Q3

INTERLEUKIN-10 -1082Q3

Abstract

Backgrounds & Aims: Some of POLYMORPHISMs are located in the promoter regions or other regulatory sequences of cytokine genes and are associated with increased or decreased amount of cytokines production. The aim of this study was to determine the rate of POLYMORPHISMs of IFN-g+874 and IL-10 -1082 in the normal population.Materials & Methods: 109 normal individuals were included in the study and genomic description was carried out using ASO-PCR method.Results: Allelic frequency of alleles A and T for IFN-g+874 were 50.92% and 49.08% respectively, and the highest genotype frequency was for the genotype A/T (54.13%). Allelic frequency of A and G for IL-10 -1082 also were 50.92% and 49.08% respectively, and genotype A/G had the highest rate among different genotypes of IL-10 -1082 (96.33%).Conclusion: The alleles A and T of IFN-g gene (+874) were in Hardy-Weinberg equilibrium, while it was not the case for A and G alleles of IL-10 gene (-1082).

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APA: Copy

ABDIRAD, I., BAGHERI, M., OMRANI, M.D., & NOROUZI PAKZAD, H.. (2010). POLYMORPHISMS OF IFN-Γ AND IL-10 GENES IN NORMAL POPULATION. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 20(4), 307-312. SID. https://sid.ir/paper/63609/en

Vancouver: Copy

ABDIRAD I., BAGHERI M., OMRANI M.D., NOROUZI PAKZAD H.. POLYMORPHISMS OF IFN-Γ AND IL-10 GENES IN NORMAL POPULATION. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2010;20(4):307-312. Available from: https://sid.ir/paper/63609/en

IEEE: Copy

I. ABDIRAD, M. BAGHERI, M.D. OMRANI, and H. NOROUZI PAKZAD, “POLYMORPHISMS OF IFN-Γ AND IL-10 GENES IN NORMAL POPULATION,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 20, no. 4, pp. 307–312, 2010, [Online]. Available: https://sid.ir/paper/63609/en

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