INFLUENCE OF DILTIAZEMON MODULATION OF CYCLOSPORINE DOSE IN KIDNEY TRANSPLANTED RECIPIENTS

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ZARGHAMI N.A.; SAMADZADEH S.; MAKHDOUMI KH.

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Journal: Studies in Medical Sciences Year:2003 | Volume:14 | Issue:1 Page(s): 32-39

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Title

INFLUENCE OF DILTIAZEMON MODULATION OF CYCLOSPORINE DOSE IN KIDNEY TRANSPLANTED RECIPIENTS

Author(s)

ZARGHAMI N.A. | SAMADZADEH S. | MAKHDOUMI KH. | Issue Writer Certificate

Keywords

CYCLOSPORINEQ3

DILTIAZEMQ4

KIDNEY TRANSPLANTATIONQ3

Abstract

Background & Aim: Calcium channel blockers are widely used in transplantation. Their immunosuppressive activity is well known and has been demonstrated in vitro and in vivo. DILTIAZEM as a calcium channel blocker is used in treatment protocol therapy along with immunosuppressive agent including CYCLOSPORINE (CsA) and corticosteroids in transplant patients for reducing toxicity of CsA by lowering dosage and keeping appropriate serum level of CYCLOSPORINE. The aim of this study was to evaluate the influence of DILTIAZEM on modulation of CYCLOSPORINE doses in transplant patients.Materials and Methods: Twenty three stable kidney transplant recipients were studied in kidney transplant section of Imam Teaching Hospital, Urmia, Iran. Thirteen patient (age range 15-55) used triple therapy including CYCLOSPORINE, azathioprine, and prednisolone along with DILTIAZEM and ten patients (age range 18-60) used only triple therapy as a control group. 243 CYCLOSPORINE measurements during the timetable of 0, 10, 20, 25, 30, 45, 60, 90, 120, 150, 180 days after transplantation under standard condition were analyzed by radioimmunoassay technique (RIA). In this study, in addition to comparing blood levels of CYCLOSPORINE, GFR (nephrotoxicity evaluation) and liver function enzymes (ALP, SGOT, SGPT) were evaluated.Results: It was shown that the serum level of CYCLOSPORINE in patients who recieved DILTIAZEM was significantly higher than those without having DILTIAZEM in their treatment protocols (p<0.05). The administered doses of CYCLOSPORINE were reduced to 25% with using DILTIAZEM which was at least equal to about 638 US dollars saving for each patient every year. In patients under triple therapy along with DILTIAZEM, GFR (as an index of nephrotoxicity) was significantly difference from control group (p<0.05) and there was no difference between two groups in liver function tests (p>0.05). Discussion: It was speculated that clinical use of DILTIAZEM could be useful on KIDNEY TRANSPLANTATION. The main findings of this research was reducing CYCLOSPORINE nephrotoxicity, increasing blood level of CsA, and as a result reducing administered dose of CYCLOSPORINE in kidney transplant recipients.

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APA: Copy

ZARGHAMI, N.A., SAMADZADEH, S., & MAKHDOUMI, KH.. (2003). INFLUENCE OF DILTIAZEMON MODULATION OF CYCLOSPORINE DOSE IN KIDNEY TRANSPLANTED RECIPIENTS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 14(1), 32-39. SID. https://sid.ir/paper/63628/en

Vancouver: Copy

ZARGHAMI N.A., SAMADZADEH S., MAKHDOUMI KH.. INFLUENCE OF DILTIAZEMON MODULATION OF CYCLOSPORINE DOSE IN KIDNEY TRANSPLANTED RECIPIENTS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2003;14(1):32-39. Available from: https://sid.ir/paper/63628/en

IEEE: Copy

N.A. ZARGHAMI, S. SAMADZADEH, and KH. MAKHDOUMI, “INFLUENCE OF DILTIAZEMON MODULATION OF CYCLOSPORINE DOSE IN KIDNEY TRANSPLANTED RECIPIENTS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 14, no. 1, pp. 32–39, 2003, [Online]. Available: https://sid.ir/paper/63628/en

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