PLASMA MEASURES OF OXIDATIVE STRESS IN Β-THALASSEMIA

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NOUROUZZADEH J.; CHIANI M.; KHADEM ANSARI M.H.; HEJAZI S.

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Journal: Studies in Medical Sciences Year:2005 | Volume:16 | Issue:2 Page(s): 65-70

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Title

PLASMA MEASURES OF OXIDATIVE STRESS IN Β-THALASSEMIA

Author(s)

NOUROUZZADEH J. | CHIANI M. | KHADEM ANSARI M.H. | HEJAZI S. | Issue Writer Certificate

Keywords

OXIDATIVE STRESSQ4

Β-THALASSIMIAQ3

IRON OVERLOADQ2

VITAMIN EQ2

MALONEDIALDEHYDEQ2

OXIDATIVE STRESSQ2

Abstract

Background and Aims: It has been proposed that IRON OVERLOAD in patients with Β-THALASSIMIA is associated with enhanced free-radical formation and/or defects in antioxidant defense. Iron facilitates the generation of free radical species (i.e. hydroxyl radical) via the Fenton reaction. Hydroxyl radicals are the main cause of tissue damage in biological systems. The aim of the present study was to examine the impact of IRON OVERLOAD in patients with β -thalassimia on plasma markers of OXIDATIVE STRESS including VITAMIN E and MALONEDIALDEHYDE. Materials and Methods: Patients with major β -thalassimia and control subjects (age: 7.67±4.4.2 years and 10.20 Patient with major β -thalassimia 5.50; n=20 each) were recruited from Imam Hospital, Urmia. Plasma MALONEDIALDEHYDE levels were analysed spectrophotometrically. VITAMIN E concentrations were measured by HPLC coupled to spectrometric detector. Results: Plasma VITAMIN E levels were lower in patients with β -thalassimia than in control subjects (l4.07±4.25 µM vs 20.04±5.02 µM; p<0.005). Patients with β -thalassimia, on the other hand, had higher MALONEDIALDEHYDE concentrations than in control subjects (0.34±0.03µM vs 0.19±0.04 µM; p<0.005). Both Iron and Ferritin levels were significantly elevated in patients with major β -thalassimia than in control subjects (160.97±45.54 µg/L vs 61.16±23.42 µg/L and 387.77±334.90 µg/L vs 50.29±34.15 µg/L, respectively). Discussion: This study has shown that OXIDATIVE STRESS resulting from IRON OVERLOAD in patients with β - thalassmia is linked with decreased antioxidant capacity and increased lipid peroxidation than in Control subjects.

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APA: Copy

NOUROUZZADEH, J., CHIANI, M., KHADEM ANSARI, M.H., & HEJAZI, S.. (2005). PLASMA MEASURES OF OXIDATIVE STRESS IN Β-THALASSEMIA. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 16(2), 65-70. SID. https://sid.ir/paper/63712/en

Vancouver: Copy

NOUROUZZADEH J., CHIANI M., KHADEM ANSARI M.H., HEJAZI S.. PLASMA MEASURES OF OXIDATIVE STRESS IN Β-THALASSEMIA. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2005;16(2):65-70. Available from: https://sid.ir/paper/63712/en

IEEE: Copy

J. NOUROUZZADEH, M. CHIANI, M.H. KHADEM ANSARI, and S. HEJAZI, “PLASMA MEASURES OF OXIDATIVE STRESS IN Β-THALASSEMIA,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 16, no. 2, pp. 65–70, 2005, [Online]. Available: https://sid.ir/paper/63712/en

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