RESULTS OF RESISTANT PROLIFERATIVE LUPUS NEPHRITIS TREATMENT WITH CYCLOSPORINE A

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SHEIKHOLESLAMI MARJAN; JAVADZADEGAN HASSAN; HAJIALILO MEHRZAD; RASI HASHEMI SEYED SADRADIN; GADAKCHI LEYLA; KHABBAZI ALI REZA

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Journal: Studies in Medical Sciences Year:2016 | Volume:27 | Issue:2 Page(s): 123-129

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Title

RESULTS OF RESISTANT PROLIFERATIVE LUPUS NEPHRITIS TREATMENT WITH CYCLOSPORINE A

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Keywords

PROLIFERATIVE LUPUS NEPHRITISQ1

CYCLOSPORINE AQ3

SYSTEMIC LUPUS ERYTHEMATOSUSQ2

RESPONSEQ1

Abstract

Background & Aims: SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) is a chronic autoimmune disease characterized by various autoantibodies formation and immune complex deposition in various organs.Lupus nephritis is a common and severe manifestation of SLE that can lead to end stage renal disease and death. The aim of this study was to evaluate the long-term efficacy of CYCLOSPORINE A in the treatment of resistant PROLIFERATIVE LUPUS NEPHRITIS.Materials & Methods: In a retrospective study, patients with PROLIFERATIVE LUPUS NEPHRITIS that were resistant to treatment with mycophenolate mofetil and/or cyclophosphamide and treated with CYCLOSPORINE A were entered to the study. They were evaluated according to the remission of the renal disease, SLE disease activity index, occurrence of end stage renal disease, mortality and side effects of treatment.Results: Twenty-five patients with biopsy proven PROLIFERATIVE LUPUS NEPHRITIS with the mean age of 30±6.9 years including 5 men (20%) and 20 women (80%) were studied. The follow up duration was 27.1±17.6 months. Proteinuria was decreased significantly during the treatment with CSA (p<0.001).Serum creatinine was stable and the changes were not significant. Partial or complete remission occurred in 60% and 32% of the patients, respectively. Prednisolone dose was reduced from 26.3 mg/d before treatment to 6.8 mg/d after treatment with CSA (P=0.001). The most common adverse event was dyspepsia.Conclusion: According to results of our study, CSA is effective in treatment of PROLIFERATIVE LUPUS NEPHRITIS.

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APA: Copy

SHEIKHOLESLAMI, MARJAN, JAVADZADEGAN, HASSAN, HAJIALILO, MEHRZAD, RASI HASHEMI, SEYED SADRADIN, GADAKCHI, LEYLA, & KHABBAZI, ALI REZA. (2016). RESULTS OF RESISTANT PROLIFERATIVE LUPUS NEPHRITIS TREATMENT WITH CYCLOSPORINE A. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 27(2), 123-129. SID. https://sid.ir/paper/63747/en

Vancouver: Copy

SHEIKHOLESLAMI MARJAN, JAVADZADEGAN HASSAN, HAJIALILO MEHRZAD, RASI HASHEMI SEYED SADRADIN, GADAKCHI LEYLA, KHABBAZI ALI REZA. RESULTS OF RESISTANT PROLIFERATIVE LUPUS NEPHRITIS TREATMENT WITH CYCLOSPORINE A. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2016;27(2):123-129. Available from: https://sid.ir/paper/63747/en

IEEE: Copy

MARJAN SHEIKHOLESLAMI, HASSAN JAVADZADEGAN, MEHRZAD HAJIALILO, SEYED SADRADIN RASI HASHEMI, LEYLA GADAKCHI, and ALI REZA KHABBAZI, “RESULTS OF RESISTANT PROLIFERATIVE LUPUS NEPHRITIS TREATMENT WITH CYCLOSPORINE A,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 27, no. 2, pp. 123–129, 2016, [Online]. Available: https://sid.ir/paper/63747/en

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