STUDY OF CEREBROSPINAL FLUID'S TOTAL CREATINE PHOSPHO KINASE ACTIVITY IN METABOLIC AND ORGANIC COMA AS A DIAGNOSTIC METHOD

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ASHRAFI H.; HESHMAT RAMIN; AGHDAMI N.; FARHADNIA P.; ANSARI M.H.

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Journal: Studies in Medical Sciences Year:2001 | Volume:12 | Issue:4 Page(s): 306-313

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Title

STUDY OF CEREBROSPINAL FLUID'S TOTAL CREATINE PHOSPHO KINASE ACTIVITY IN METABOLIC AND ORGANIC COMA AS A DIAGNOSTIC METHOD

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Keywords

ORGANIC COMAQ4

METABOLIC COMAQ4

CREATINE PHOSPHOKINASEQ4

CEREBROSPINAL FLUIDQ3

Abstract

Introduction: There are two main etiologic groups of coma: Metabolic and Organic. Recently, evaluation of CEREBROSPINAL FLUID's (CSF) CREATINE PHOSPHOKINASE enzyme (CPK) is suggested for differentiation of organic and METABOLIC COMAs. Present study has been designed and conducted to determination and comparison of CPK level in CSF of patients with metabolic and ORGANIC COMA.Materials & Methods: A total of 72 patients were studied in this case-control study (18 cases with proven ORGANIC COMA, 14 cases with proven METABOLIC COMA and 36 cases as control group). Creatine Phospho-kinase activity was estimated in CSF and the results were analyzed by SPSS software and parametric tests in three groups.Results: The mean CPK enzyme levels in CSF were 15.56 mu/ml in ORGANIC COMA, 5.93 mu/ml in METABOLIC COMA and 0.32 mu/ml in control group. There were significant differences in comparison of two types of coma with each other and with control group.The results indicate that CPK level in CSF increases in patients with coma but this elevation is more noticeable in ORGANIC COMA than metabolic. Discussion: So, measurement of CSF-CPK level can help for differentiation of metabolic and ORGANIC COMA in association with other clinical and paraclinical findings.

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APA: Copy

ASHRAFI, H., HESHMAT, RAMIN, AGHDAMI, N., FARHADNIA, P., & ANSARI, M.H.. (2001). STUDY OF CEREBROSPINAL FLUID'S TOTAL CREATINE PHOSPHO KINASE ACTIVITY IN METABOLIC AND ORGANIC COMA AS A DIAGNOSTIC METHOD. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 12(4), 306-313. SID. https://sid.ir/paper/63822/en

Vancouver: Copy

ASHRAFI H., HESHMAT RAMIN, AGHDAMI N., FARHADNIA P., ANSARI M.H.. STUDY OF CEREBROSPINAL FLUID'S TOTAL CREATINE PHOSPHO KINASE ACTIVITY IN METABOLIC AND ORGANIC COMA AS A DIAGNOSTIC METHOD. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2001;12(4):306-313. Available from: https://sid.ir/paper/63822/en

IEEE: Copy

H. ASHRAFI, RAMIN HESHMAT, N. AGHDAMI, P. FARHADNIA, and M.H. ANSARI, “STUDY OF CEREBROSPINAL FLUID'S TOTAL CREATINE PHOSPHO KINASE ACTIVITY IN METABOLIC AND ORGANIC COMA AS A DIAGNOSTIC METHOD,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 12, no. 4, pp. 306–313, 2001, [Online]. Available: https://sid.ir/paper/63822/en

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