THE EFFECT OF ALUMINIUM INJECTION IN ARCUATE NUCLEUSE ON PAIN THRESHOLD IN THE MALE RAT

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SHAHRAKI M.R.; ZAHEDIASL S.; SARKAKI A.R.

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Journal: Studies in Medical Sciences Year:2001 | Volume:12 | Issue:4 Page(s): 344-351

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Title

THE EFFECT OF ALUMINIUM INJECTION IN ARCUATE NUCLEUSE ON PAIN THRESHOLD IN THE MALE RAT

Author(s)

SHAHRAKI M.R. | ZAHEDIASL S. | SARKAKI A.R. | Issue Writer Certificate

Keywords

ALUMINIUMQ4

PAIN THRESHOLDQ2

MALE RATQ3

ARCUATE NUCLEUSQ3

Abstract

Introduction: ALUMINIUM is an important voltage sensitive calcium channels blocker and enter the body from different sources. This ion interfere with biological function of Ca2+ ion. Because the ARCUATE NUCLEUSe has beta-endorphin neuron which effect on pain control, this experiment was performed to study the effect of ALUMINIUM microinjection on MALE RAT's PAIN THRESHOLD.Materials and method: The experiment performed on four group of MALE RATs (n=36), that the actuate nucleus were bilateral cannulated by sterotaxic surgery. Test group received 100 nl ACSF containing 0.15 pmol ALUMINIUM in each side of the ARCUATE NUCLEUS for 15 days. Two series of these animals after cannulation received the same volume of ACSF with pH =7.2 and 3.4. The shame control group did not received any agent after cannulation. At the end of experiment, animals PAIN THRESHOLD was measured by tail emmersion method. Statistic test was student t-test. The results are expressed as mean±SE and P<0.05 were significant.Results: Results showed that the PAIN THRESHOLD in that group received aluminum in ARCUATE NUCLEUS (6.78±0.34 mse) decrease significantly compared with shame control PAIN THRESHOLD (8.61±0. mse) group (p<0.05).Conclusion: These result indicate that injection of aluminum in MALE RAT's ARCUATE NUCLEUS, can be affect on PAIN THRESHOLD. Further studies will probably show the exact mechanism of aluminum ion on PAIN THRESHOLD.

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APA: Copy

SHAHRAKI, M.R., ZAHEDIASL, S., & SARKAKI, A.R.. (2001). THE EFFECT OF ALUMINIUM INJECTION IN ARCUATE NUCLEUSE ON PAIN THRESHOLD IN THE MALE RAT. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 12(4), 344-351. SID. https://sid.ir/paper/63823/en

Vancouver: Copy

SHAHRAKI M.R., ZAHEDIASL S., SARKAKI A.R.. THE EFFECT OF ALUMINIUM INJECTION IN ARCUATE NUCLEUSE ON PAIN THRESHOLD IN THE MALE RAT. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2001;12(4):344-351. Available from: https://sid.ir/paper/63823/en

IEEE: Copy

M.R. SHAHRAKI, S. ZAHEDIASL, and A.R. SARKAKI, “THE EFFECT OF ALUMINIUM INJECTION IN ARCUATE NUCLEUSE ON PAIN THRESHOLD IN THE MALE RAT,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 12, no. 4, pp. 344–351, 2001, [Online]. Available: https://sid.ir/paper/63823/en

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