A COMPARATIVE STUDY OF EXTRA – AMNIOTIC SALINE INFUSION AND HIGH DOSE OXYTOCIN WITH PROSTAGLANDIN E2 SUPPOSITORY AND HIGH DOSE OXYTOCIN IN PRE - INDUCTION CERVICAL RIPENING IN SECOND TRIMESTER PREGNANCIES

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AMIRABI A.; GOL MOHAMMADLOU S.; SALARILAK SH.; KHEYBARI L.

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Journal: Studies in Medical Sciences Year:2009 | Volume:19 | Issue:4 Page(s): 295-301

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Title

A COMPARATIVE STUDY OF EXTRA – AMNIOTIC SALINE INFUSION AND HIGH DOSE OXYTOCIN WITH PROSTAGLANDIN E2 SUPPOSITORY AND HIGH DOSE OXYTOCIN IN PRE - INDUCTION CERVICAL RIPENING IN SECOND TRIMESTER PREGNANCIES

Author(s)

AMIRABI A. | GOL MOHAMMADLOU S. | SALARILAK SH. | KHEYBARI L. | Issue Writer Certificate

Keywords

SECOND TRIMESTER PREGNANCIESQ3

EXTRA-AMNIOTIC SALINE INFUSIONQ3

PROSTAGLANDIN E2 SUPPOSITORYQ3

USING INTRAVENOUS OXYTOCINQ3

CERVICAL RIPENINGQ3

Abstract

Background &Aims: It is necessary to terminate pregnancy for fetal or maternal indications in some SECOND TRIMESTER PREGNANCIES. The cervix is usually unripe in 2nd trimester, so pre-induction ripening is mandatory. The aim of this study is to compare the efficacy of EXTRA-AMNIOTIC SALINE INFUSION with PROSTAGLANDIN E2 SUPPOSITORY in pre-induction CERVICAL RIPENING in 2nd trimester pregnancies.Materials & Methods: In this study, women (n= 80) with indications of termination of pregnancy (range 14-28 weeks) and bishop scores of 3 and lower were assigned randomly to receive EXTRA-AMNIOTIC SALINE INFUSION (2ML/ min) or prostaglandin suppository (6 mg).We induced uterine contractions USING INTRAVENOUS OXYTOCIN only when contractions had not commenced by 6 hours after EXTRA-AMNIOTIC SALINE INFUSION and 4 hours after prostaglandin. We assessed ripening efficacy, success and failure of therapy, mean time of induction, and complications of two methods. Statistical analysis was done based on the data. Results: The mean pre-ripening bishop score was l.2±0.53 in group 1 (extra-amniotic saline infusion) and 1.68±0.66 in group 2 (prostaglandin). The mean post- ripening BSC was 4.5±2.14 in group I and 3 ± 1.6 in group 2, which was significant. There were 20 (%50) fetus expulsion in group 1 and 8 (20%) in group 2. The mean time for induction was 17.27 ± 8.38 hours in group 1 and 20.9 ±6.17 hours in group 2, which was statistically significant. One patient in group 1 had vaginal bleeding because of warfarin use. Three patients had nausea in group 2. There were no other complications in both methods. Conclusion: CERVICAL RIPENING by EXTRA-AMNIOTIC SALINE INFUSION is faster and more effective than 6 mg PROSTAGLANDIN E2 SUPPOSITORY, resulting in a higher rate of fetus expulsion in 2nd trimester.

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APA: Copy

AMIRABI, A., GOL MOHAMMADLOU, S., SALARILAK, SH., & KHEYBARI, L.. (2009). A COMPARATIVE STUDY OF EXTRA – AMNIOTIC SALINE INFUSION AND HIGH DOSE OXYTOCIN WITH PROSTAGLANDIN E2 SUPPOSITORY AND HIGH DOSE OXYTOCIN IN PRE - INDUCTION CERVICAL RIPENING IN SECOND TRIMESTER PREGNANCIES. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 19(4), 295-301. SID. https://sid.ir/paper/63855/en

Vancouver: Copy

AMIRABI A., GOL MOHAMMADLOU S., SALARILAK SH., KHEYBARI L.. A COMPARATIVE STUDY OF EXTRA – AMNIOTIC SALINE INFUSION AND HIGH DOSE OXYTOCIN WITH PROSTAGLANDIN E2 SUPPOSITORY AND HIGH DOSE OXYTOCIN IN PRE - INDUCTION CERVICAL RIPENING IN SECOND TRIMESTER PREGNANCIES. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2009;19(4):295-301. Available from: https://sid.ir/paper/63855/en

IEEE: Copy

A. AMIRABI, S. GOL MOHAMMADLOU, SH. SALARILAK, and L. KHEYBARI, “A COMPARATIVE STUDY OF EXTRA – AMNIOTIC SALINE INFUSION AND HIGH DOSE OXYTOCIN WITH PROSTAGLANDIN E2 SUPPOSITORY AND HIGH DOSE OXYTOCIN IN PRE - INDUCTION CERVICAL RIPENING IN SECOND TRIMESTER PREGNANCIES,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 19, no. 4, pp. 295–301, 2009, [Online]. Available: https://sid.ir/paper/63855/en

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