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Information Journal Paper

Title

EFFECT OF NIGELLA SATIVA ON ISCHEMIA-REPERFUSION INDUCED RAT KIDNEY DAMAGE

Pages

  986-992

Keywords

ISCHEMIA-REPERFUSION INJURY (IRI) 

Abstract

 Objective(s): There are a few previously reported studies about the effect of NIGELLA SATIVA oil on renal ischemia-reperfusion injury (IRI). The aim of the present study was to test the hypothesis whether pre- or post-treatment with N. sativa hydroalcoholic extract (NSE) would reduce tissue injury and oxidative damages in a clinically relevant rat model of renal IRI.Materials and Methods: IRI was induced by clamping of bilateral renal arteries for 40 min fallowed by reperfusion for 180 min. NSE was prepared in a Soxhlet extractor and administrated with doses of 150 mg/kg or 300 mg/kg at 1 hr before ischemia induction (P-150 and 300) or at the beginning of reperfusion phase (T-150 and 300), via jugular catheter intravenously. The KIDNEYs were then removed and subjected to biochemical analysis, COMET ASSAY or histopathological examination.Results: The KIDNEYs of untreated IRI rats had a higher histopathological score (P<0.001), while in P-150, as well as T-150 and T-300 groups tubular lesions significantly decreased (P<0.001). Pre- and post-treatment with NSE also resulted in a significant decrease in malondialdehyde (MDA) level (P<0.001) and DNA damage (P<0.001) that were increased by renal I/R injury. NSE treatment also significantly restore (P<0.01) the decrease in renal thiol content caused by IRI.Conclusion: The present study shows N. sativa extract has marked protective action against renal IRI, which may be partly due to its antioxidant effects.

Cites

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    APA: Copy

    HAVAKHAH, SHAHRZAD, SADEGHNIA, HAMID REZA, HAJZADEH, MOSA AL REZA, MOHAMMADIAN ROSHAN, NAMA, SHAFIEE, SOMAYEH, HOSSEINZADEH, HOSSEIN, MOHARERI, NARGES, & KHAJAVI RAD, ABOLFAZL. (2014). EFFECT OF NIGELLA SATIVA ON ISCHEMIA-REPERFUSION INDUCED RAT KIDNEY DAMAGE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(12), 986-992. SID. https://sid.ir/paper/638764/en

    Vancouver: Copy

    HAVAKHAH SHAHRZAD, SADEGHNIA HAMID REZA, HAJZADEH MOSA AL REZA, MOHAMMADIAN ROSHAN NAMA, SHAFIEE SOMAYEH, HOSSEINZADEH HOSSEIN, MOHARERI NARGES, KHAJAVI RAD ABOLFAZL. EFFECT OF NIGELLA SATIVA ON ISCHEMIA-REPERFUSION INDUCED RAT KIDNEY DAMAGE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(12):986-992. Available from: https://sid.ir/paper/638764/en

    IEEE: Copy

    SHAHRZAD HAVAKHAH, HAMID REZA SADEGHNIA, MOSA AL REZA HAJZADEH, NAMA MOHAMMADIAN ROSHAN, SOMAYEH SHAFIEE, HOSSEIN HOSSEINZADEH, NARGES MOHARERI, and ABOLFAZL KHAJAVI RAD, “EFFECT OF NIGELLA SATIVA ON ISCHEMIA-REPERFUSION INDUCED RAT KIDNEY DAMAGE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 12, pp. 986–992, 2014, [Online]. Available: https://sid.ir/paper/638764/en

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