EFFECT OF THIOPERAMIDEON THE HISTIDINE DECARBOXYLASE ACTIVITY IN RAT BRAIN

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GHOUJEGH D.; SAFARI Y.H.

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Journal: Studies in Medical Sciences Year:2001 | Volume:12 | Issue:1 Page(s): 65-73

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Information Journal Paper

Title

EFFECT OF THIOPERAMIDEON THE HISTIDINE DECARBOXYLASE ACTIVITY IN RAT BRAIN

Author(s)

GHOUJEGH D. | SAFARI Y.H. | Issue Writer Certificate

Keywords

HISTIDINE DECARBOXYLASEQ4

HISTAMINEQ4

THIOPERAMIDEQ4

Abstract

Introduction: THIOPERAMIDE, an histamin H3 receptor antagonist, blocks HISTAMINE release from the HISTAMINErgic, presynapse, thus affecting HISTAMINE and its metabolite levels in the brain and being able to modify activity of the HISTAMINErgic neuron system. The multiple function of histamin as a chemical messenger in cell to cell communication have been progressively reveals. HISTAMINE is stored in, and released from, various cellular populations including immunoglobulin E receptor bearing cells, endocrine cells and neurons in the central or peripheral nervous system. HISTIDINE DECARBOXYLASE (E.C.4.1.1.22) the enzyme which forms HISTAMINE in mammalian tissues.Method & Material: A simple method for the assay of HISTIDINE DECARBOXYLASE activity in brain tissue was studied. Rats were injected with saline or THIOPERAMIDE (50 micro g/Kg) i.p.. One hour later, the animal was scarified and the brain was homogenate. The supernatant of homogenates was placed in tube and centrifuge at 4500 *g for 30 min. The activity of HISTIDINE DECARBOXYLASE was assayed by measuring the HISTAMINE formed spectrophotometer by the reaction with 2,4,6-trinitrobenzene sulfonate at 420 nm.Results & Discussion: Results show that the enzyme activity was highest in the hypothalamus, lower in the cerebrum. The brain HISTIDINE DECARBOXYLASE activity was decreased by THIOPERAMIDE 1 hr after administration in the thalamus and cerebrum.

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APA: Copy

GHOUJEGH, D., & SAFARI, Y.H.. (2001). EFFECT OF THIOPERAMIDEON THE HISTIDINE DECARBOXYLASE ACTIVITY IN RAT BRAIN. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 12(1), 65-73. SID. https://sid.ir/paper/64049/en

Vancouver: Copy

GHOUJEGH D., SAFARI Y.H.. EFFECT OF THIOPERAMIDEON THE HISTIDINE DECARBOXYLASE ACTIVITY IN RAT BRAIN. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2001;12(1):65-73. Available from: https://sid.ir/paper/64049/en

IEEE: Copy

D. GHOUJEGH, and Y.H. SAFARI, “EFFECT OF THIOPERAMIDEON THE HISTIDINE DECARBOXYLASE ACTIVITY IN RAT BRAIN,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 12, no. 1, pp. 65–73, 2001, [Online]. Available: https://sid.ir/paper/64049/en

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