EFFECT OF ANGIOTENSIN-COVERTIENNG EZYME (ACE) INSERTION (I) / DELETION (D) GENE POLYMORPHISM ON SERUM ACE LEVEL IN IRANIAN PEOPLE

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MOHAMMADI F.; ZABANI S.; ZIEAEI A.A.

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Journal: Studies in Medical Sciences Year:2001 | Volume:12 | Issue:1 Page(s): 74-82

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Title

EFFECT OF ANGIOTENSIN-COVERTIENNG EZYME (ACE) INSERTION (I) / DELETION (D) GENE POLYMORPHISM ON SERUM ACE LEVEL IN IRANIAN PEOPLE

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Keywords

ANGIOTENSIM I CONVERTING ENZYME (ACE)Q4

ACE GENE POLYMORPHISMQ4

Abstract

Introduction: To determine the incidence of ACE I/D gene polymorphism and It's effect on serum ACE level. Material and method: This prospective analytical study was done on 88 healthy kidney donate. The serum ACE determined by spectophotometric assay and genotype by polymerase chain reaction (PCR).Result: 88 healthy individual (70 males: %80 and 18 females: 20%) was selected for the study. Mean age for each genotype were: II=29,88 +/- 8/07, ID=31/04+/- 7/06, DD=29/29+/- 6/82. The frequency of deletion and insertion alleles were 0/48 and 0/51 respectively. Mean serum ACE +/- SD in each genotype were II=32/06+/- 24/2, ID=36/25 +/- 20/87, DD=50/68+/- 24/59.Conclusion: In this study we show the effect of ACE I/D gene polymorphism on the serum ACE level in Iranian people. Frequency of I,D alleles were 51/15% and 48/85% respectively. The mean of serum ACE level in each genotype was lower in female than male but due to small number of females documentation with greater number of cases is recommended. This is the first description of ACE GENE POLYMORPHISM in Iranian population which can be used as a pilot for future steadies.

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APA: Copy

MOHAMMADI, F., ZABANI, S., & ZIEAEI, A.A.. (2001). EFFECT OF ANGIOTENSIN-COVERTIENNG EZYME (ACE) INSERTION (I) / DELETION (D) GENE POLYMORPHISM ON SERUM ACE LEVEL IN IRANIAN PEOPLE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 12(1), 74-82. SID. https://sid.ir/paper/64050/en

Vancouver: Copy

MOHAMMADI F., ZABANI S., ZIEAEI A.A.. EFFECT OF ANGIOTENSIN-COVERTIENNG EZYME (ACE) INSERTION (I) / DELETION (D) GENE POLYMORPHISM ON SERUM ACE LEVEL IN IRANIAN PEOPLE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2001;12(1):74-82. Available from: https://sid.ir/paper/64050/en

IEEE: Copy

F. MOHAMMADI, S. ZABANI, and A.A. ZIEAEI, “EFFECT OF ANGIOTENSIN-COVERTIENNG EZYME (ACE) INSERTION (I) / DELETION (D) GENE POLYMORPHISM ON SERUM ACE LEVEL IN IRANIAN PEOPLE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 12, no. 1, pp. 74–82, 2001, [Online]. Available: https://sid.ir/paper/64050/en

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