ASSESSMENT OF HTLV-I PROVIRAL LOAD, HIV VIRAL LOAD AND CD4 T CELL COUNT IN INFECTED SUBJECTS; WITH AN EMPHASIS ON VIRAL REPLICATION IN CO-INFECTION

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EBRAHIMI HOSSEIN; REZAEE SEYYED ABDOLRAHIM; VALIZADEH NARGES; VAKILI ROSITA; RAFATPANAH HOUSHANG

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Journal: Iranian Journal of Basic Medical Sciences Year:2014 | Volume:17 | Issue:1 Page(s): 49-54

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Title

ASSESSMENT OF HTLV-I PROVIRAL LOAD, HIV VIRAL LOAD AND CD4 T CELL COUNT IN INFECTED SUBJECTS; WITH AN EMPHASIS ON VIRAL REPLICATION IN CO-INFECTION

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Keywords

HIV VIRAL LOAD

HTLV-I/HIV CO-INFECTION

HTLV-I PROVIRAL LOAD

LYMPHOCYTES

Abstract

Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV-I and HIV co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated.Materials and Methods: In this study, 40 subjects were selected; 14 HIV infected, 20 HTLV-I infected and 6 HTLV-I/HIV co-infected subjects. The amount of viruses was measured using qPCR TaqMan method and CD4 and CD8 LYMPHOCYTES were assessed by flow cytometry.Results: The mean viral load of HIV infected subjects and HTLV-I infected individuals were 134626.07±60031.07 copies/ml and 373.6±143.3 copies/104 cells, respectively. The mean HIV VIRAL LOAD in co-infected group was 158947±78203.59 copies/ml which is higher than HIV infected group. The mean proviral load of HTLV-I in co-infected group was 222.33±82.56 copies/ml which is lower than HTLV-I infected group (P<0.05). Also, the mean white blood cell count was higher in co-infected group (5666.67±1146.49 cells/ml). However, the differences between these subjects did not reach to a statistical significance within 95% confidence interval level (P =0.1). No significant differences were observed regarding CD4 and CD8 positive LYMPHOCYTES between these groups.Conclusion: HTLV-I/HIV CO-INFECTION might promote HIV replication and could reduce the HTLV-I PROVIRAL LOAD, in infected cells. Considering the presence of both viruses in Khorasan provinces, it encourages researchers and health administrators to have a better understanding of co-infection outcome.

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APA: Copy

EBRAHIMI, HOSSEIN, REZAEE, SEYYED ABDOLRAHIM, VALIZADEH, NARGES, VAKILI, ROSITA, & RAFATPANAH, HOUSHANG. (2014). ASSESSMENT OF HTLV-I PROVIRAL LOAD, HIV VIRAL LOAD AND CD4 T CELL COUNT IN INFECTED SUBJECTS; WITH AN EMPHASIS ON VIRAL REPLICATION IN CO-INFECTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(1), 49-54. SID. https://sid.ir/paper/640532/en

Vancouver: Copy

EBRAHIMI HOSSEIN, REZAEE SEYYED ABDOLRAHIM, VALIZADEH NARGES, VAKILI ROSITA, RAFATPANAH HOUSHANG. ASSESSMENT OF HTLV-I PROVIRAL LOAD, HIV VIRAL LOAD AND CD4 T CELL COUNT IN INFECTED SUBJECTS; WITH AN EMPHASIS ON VIRAL REPLICATION IN CO-INFECTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(1):49-54. Available from: https://sid.ir/paper/640532/en

IEEE: Copy

HOSSEIN EBRAHIMI, SEYYED ABDOLRAHIM REZAEE, NARGES VALIZADEH, ROSITA VAKILI, and HOUSHANG RAFATPANAH, “ASSESSMENT OF HTLV-I PROVIRAL LOAD, HIV VIRAL LOAD AND CD4 T CELL COUNT IN INFECTED SUBJECTS; WITH AN EMPHASIS ON VIRAL REPLICATION IN CO-INFECTION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 1, pp. 49–54, 2014, [Online]. Available: https://sid.ir/paper/640532/en

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