THE EFFECTS OF MORPHINE ON FREQUENCY OF HIPPOCAMPAL SEIZURE IN NEONATE MICE, IN VITRO

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SABOURI E.; SADAGHIANI M.; KARIMIPOUR M.; MIRZA AGHA ZADEH J.

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Journal: Studies in Medical Sciences Year:2006 | Volume:17 | Issue:3 Page(s): 196-202

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Title

THE EFFECTS OF MORPHINE ON FREQUENCY OF HIPPOCAMPAL SEIZURE IN NEONATE MICE, IN VITRO

Author(s)

SABOURI E. | SADAGHIANI M. | KARIMIPOUR M. | MIRZA AGHA ZADEH J. | Issue Writer Certificate

Keywords

HOLE HIPPOCAMPUSQ3

MORPHINEQ3

NALOXONEQ3

SEIZUREQ3

FREQUENCYQ3

LOW MG2+ ACSFQ3

Abstract

Background &Aims: This study was designed to determine effects of MORPHINE on FREQUENCY of different components of SEIZURE induced by Low Mg2+ ACSF in wHOLE HIPPOCAMPUS preparation of neonate mice.Materials and Methods: C57/BL6 mice 11 to 19 days of age were used. Animals anaesthetized and the brain was removed (n=25) and placed in ice-cold continuously oxygenated ACSF. Then the hippocampi was dissected and incubated in normal ACSF at room temperature for one hour before electrophysiologic recording. SEIZURE activity was induced by perfusing the hippocampus with Low Mg2+ ACSF. Extracellular recordings were performed mainly in the CA1 pyramidal cell layer. SEIZURE activity was quantified by measuring the FREQUENCY of the ictal events.Results: All applied concentrations of MORPHINE and NALOXONE 10 mM decreased the FREQUENCY of SEIZURE more effectively on tonic part of SEIZURE. NALOXONE not only unblocked the the effects of MORPHINE on the FREQUENCY of SEIZURE, but also markedly suppressed the FREQUENCY of epileptiform activities. In addition, combined application of MORPHINE and NALOXONE completely blocked the tonic-clonic part of the SEIZUREs. Discussion: Our results indicate that MORPHINE may decrease the FREQUENCY of hippocampal SEIZURE through different receptors other than opioid receptors because NALOXONE as an opioid receptors antagonist unblocked these inhibitory effects of MORPHINE.

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APA: Copy

SABOURI, E., SADAGHIANI, M., KARIMIPOUR, M., & MIRZA AGHA ZADEH, J.. (2006). THE EFFECTS OF MORPHINE ON FREQUENCY OF HIPPOCAMPAL SEIZURE IN NEONATE MICE, IN VITRO. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 17(3), 196-202. SID. https://sid.ir/paper/64064/en

Vancouver: Copy

SABOURI E., SADAGHIANI M., KARIMIPOUR M., MIRZA AGHA ZADEH J.. THE EFFECTS OF MORPHINE ON FREQUENCY OF HIPPOCAMPAL SEIZURE IN NEONATE MICE, IN VITRO. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2006;17(3):196-202. Available from: https://sid.ir/paper/64064/en

IEEE: Copy

E. SABOURI, M. SADAGHIANI, M. KARIMIPOUR, and J. MIRZA AGHA ZADEH, “THE EFFECTS OF MORPHINE ON FREQUENCY OF HIPPOCAMPAL SEIZURE IN NEONATE MICE, IN VITRO,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 17, no. 3, pp. 196–202, 2006, [Online]. Available: https://sid.ir/paper/64064/en

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