EVALUATION OF POSSIBLE CYOTOXIC EFFECT OF ZINC ON MOLT-4 CELL LINE

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TOKMEH DASHI H.; OUSATI ASHTIANI F.; POURFATH ELAH A.A.

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Journal: Studies in Medical Sciences Year:2003 | Volume:14 | Issue:3 Page(s): 174-179

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Title

EVALUATION OF POSSIBLE CYOTOXIC EFFECT OF ZINC ON MOLT-4 CELL LINE

Author(s)

TOKMEH DASHI H. | OUSATI ASHTIANI F. | POURFATH ELAH A.A. | Issue Writer Certificate

Keywords

ZINCQ3

MOLT-4 CELLQ4

CYTOTOXICITYQ3

CELL CULTVREQ3

Abstract

Introduction: ZINC has important effects on structural and functional activities of many enzymes, specially regulation of immune system. This study was carried out to examine the in vitro cytotoxic effects of ZINC on MOLT-4 CELL line. Materials & Methods: In this study (by cell culture) the cell line was exposed to different concentration of ZINC followed by incubation (37°C, 5% Co2) at various time points (12 to 72 hrs). Viability and proliferation of MOLT-4 CELLs were then evaluated with florecent (Ethidium - Bromide and Acridine - Orange) staining and then analysed data by package of SPss (Dunet and Analysis variants test) were studied and evaluated. Results: The results showed almost different responses to different amount o/ZINC by the MOLT-4 CELLs less than 100p.M at different incubation time points had no effects on cell line when compared to the controls. Higher concentrations of ZINC (200-500 µM) viability diminished to 80-85% at 12 hrs and less than 50% at 24 hrs of incubation times. Discussion: We conclude that Zn had dose-dependant cytotoxic effect on MOLT-4 CELLs and probably application for immune-modulation.

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APA: Copy

TOKMEH DASHI, H., OUSATI ASHTIANI, F., & POURFATH ELAH, A.A.. (2003). EVALUATION OF POSSIBLE CYOTOXIC EFFECT OF ZINC ON MOLT-4 CELL LINE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 14(3), 174-179. SID. https://sid.ir/paper/64093/en

Vancouver: Copy

TOKMEH DASHI H., OUSATI ASHTIANI F., POURFATH ELAH A.A.. EVALUATION OF POSSIBLE CYOTOXIC EFFECT OF ZINC ON MOLT-4 CELL LINE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2003;14(3):174-179. Available from: https://sid.ir/paper/64093/en

IEEE: Copy

H. TOKMEH DASHI, F. OUSATI ASHTIANI, and A.A. POURFATH ELAH, “EVALUATION OF POSSIBLE CYOTOXIC EFFECT OF ZINC ON MOLT-4 CELL LINE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 14, no. 3, pp. 174–179, 2003, [Online]. Available: https://sid.ir/paper/64093/en

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