USAGE OF APROTININ FOR REDUCING OF POSTOPERATIVE HAEMORRHAGE AND FRESH FROZEN PLASMA CONSUMPTION

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SABZI F.; JALILI Z.; HADJIMORADI B.

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Journal: Studies in Medical Sciences Year:2003 | Volume:14 | Issue:3 Page(s): 167-173

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Title

USAGE OF APROTININ FOR REDUCING OF POSTOPERATIVE HAEMORRHAGE AND FRESH FROZEN PLASMA CONSUMPTION

Author(s)

SABZI F. | JALILI Z. | HADJIMORADI B. | Issue Writer Certificate

Keywords

OPEN HEART OPEARATIONQ3

HAEMORRHAGEQ2

ANTI HEMORRHAGE DRUGSQ4

APROTININQ4

Abstract

Introduction: APROTININ has been used increasingly to reduce postoperative blood loss in open - heart operation. Because of it's potential for complications and high cost, it will be reasonable to use APROTININ more selectively in small dose in prime solution of pump. Materials & Methods: We prospectively studied the effect of preoperative low dose APROTININ [2 million units (230 mg)] on blood loss and transfusion requirement in patients undergoing cardiopulmonary bypass. 150 patients were randomly assigned to two groups: prophylactic low dose APROTININ (group 1) and a non - medicated control group (group 2). The two groups were compared in all demographic and operative variables. Results: Postoperative chest tube drainage was significantly decreased in APROTININ group compared with the control group (372.73 ml in group 1 and 482.2 ml in group 2, p<0.05) no significant difference was seen between two group in transfusion requirement (p>0.05). The use of fresh frozen plasma in group 1 was significantly less than in group2 (469.87 ml versus 680.69 ml p<0.05). Discussion: Our results suggest that prophylactic APROTININ reduces blood loss and FFP requirements compared with non - medicated group. Prophylactic use of APROTININ has been shown to decrease postoperative blood loss and transfusion requirements in patients undergoing cardiac operations with extracorporeal circulation.

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APA: Copy

SABZI, F., JALILI, Z., & HADJIMORADI, B.. (2003). USAGE OF APROTININ FOR REDUCING OF POSTOPERATIVE HAEMORRHAGE AND FRESH FROZEN PLASMA CONSUMPTION. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 14(3), 167-173. SID. https://sid.ir/paper/64097/en

Vancouver: Copy

SABZI F., JALILI Z., HADJIMORADI B.. USAGE OF APROTININ FOR REDUCING OF POSTOPERATIVE HAEMORRHAGE AND FRESH FROZEN PLASMA CONSUMPTION. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2003;14(3):167-173. Available from: https://sid.ir/paper/64097/en

IEEE: Copy

F. SABZI, Z. JALILI, and B. HADJIMORADI, “USAGE OF APROTININ FOR REDUCING OF POSTOPERATIVE HAEMORRHAGE AND FRESH FROZEN PLASMA CONSUMPTION,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 14, no. 3, pp. 167–173, 2003, [Online]. Available: https://sid.ir/paper/64097/en

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