STUDY ON EVALUATION RELATION BETWEEN PATHOLOGIC FINDING WITH SERUM TPSA OF PATIENTS WITH URINARY OBSTRUCTIVE SYMPTOMS IN SHARIATI HOSPITAL (1998-2000)

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KAMALIAN N.A.; ENSANI F.; ABD ELAHI A.

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Journal: Studies in Medical Sciences Year:2001 | Volume:12 | Issue:2 Page(s): 112-119

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Title

STUDY ON EVALUATION RELATION BETWEEN PATHOLOGIC FINDING WITH SERUM TPSA OF PATIENTS WITH URINARY OBSTRUCTIVE SYMPTOMS IN SHARIATI HOSPITAL (1998-2000)

Author(s)

KAMALIAN N.A. | ENSANI F. | ABD ELAHI A. | Issue Writer Certificate

Keywords

PROSTATE CARCINOMAQ4

GLEASON SCOREQ4

PSAQ3

Abstract

Introduction: Prostatic carcinom is the most prevalent malignancy in men, and 10% of m0l1alitiesdue to cancer. In Iran as a result of increasing life expectancy, its incidences risimg. There's increasing need for easy, economic and sensitive methods to diagnose prostatic cancer in early stage.Methods & Materials: In order to evaluate dignostic role of tPSA in benign and malignant prostatic lesion, 130 patients between 54-78 years old, presenting with ulinary obstructive symptoms, were selected serum level of PSA and prostatic needle biopsy carried out in all case. Morphologic features, BPH or carcinomca and grade of carcinoma according to Gleason system, were compared with serum tPSA level.Results: The results showed that 42.9% of cases were adenocarcinoma and 57.1ro of cases were BPH. The most prevalent histologic score was score 5 (36.7%). The average of tPSA in BPH groups was 28.617 with 91.728 standard deviation and in the most prevalent malignant scroe the avemge of tPSA was 118.218 with 385.186 standard deviation Consideling the cut off point 10 ng/ml sensivity of this test is 44.8% and its specifity is 69.80%. Positive and negative predictive value is 78.3% and 34/1%, respectively. The average tPSA differences in these two groups by nonparametral test (Mann-whitney) is meaning full (P value=0000203).Discussion: Incidence of BPH higher than adenocarcinoma and serum PSA in both is elevated and its elevation in adenocarcinoma is higher than BPH and this augmentation was heightening with increasing of histologic score. This test had a good sensitivity and specifity and aside TR and Tran rectal sonography can use this test from of a screening test in early diagnosis of prostatic cancer. As claimed by studies in order to increase specifity of tPSA, using the other methods like PSAD and % tPSA are helpful. The results from these two tests were the same %tPSA <25% and PSAD>0.078, 95% of prostatic cancers were detected in early stalfes.Owing to easy performance, unnecessary rectal sonography and its ability to predict tomur condition, regarding to biologic behavior and histologic score, %tPSA can be an auxiliary test besides tPSA.

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APA: Copy

KAMALIAN, N.A., ENSANI, F., & ABD ELAHI, A.. (2001). STUDY ON EVALUATION RELATION BETWEEN PATHOLOGIC FINDING WITH SERUM TPSA OF PATIENTS WITH URINARY OBSTRUCTIVE SYMPTOMS IN SHARIATI HOSPITAL (1998-2000). STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 12(2), 112-119. SID. https://sid.ir/paper/64163/en

Vancouver: Copy

KAMALIAN N.A., ENSANI F., ABD ELAHI A.. STUDY ON EVALUATION RELATION BETWEEN PATHOLOGIC FINDING WITH SERUM TPSA OF PATIENTS WITH URINARY OBSTRUCTIVE SYMPTOMS IN SHARIATI HOSPITAL (1998-2000). STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2001;12(2):112-119. Available from: https://sid.ir/paper/64163/en

IEEE: Copy

N.A. KAMALIAN, F. ENSANI, and A. ABD ELAHI, “STUDY ON EVALUATION RELATION BETWEEN PATHOLOGIC FINDING WITH SERUM TPSA OF PATIENTS WITH URINARY OBSTRUCTIVE SYMPTOMS IN SHARIATI HOSPITAL (1998-2000),” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 12, no. 2, pp. 112–119, 2001, [Online]. Available: https://sid.ir/paper/64163/en

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