EFFECT OF FULLERENE NANOPARTICLES ON BRAIN INFARCTION AND HISTOPATHOLOGICAL CHANGES DURING TRANSIENT AND FOCAL CEREBRAL ISCHEMIA IN RAT

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Aryafar Masiha; MOHAMMADI MOHAMMAD TAGHI

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Journal: Studies in Medical Sciences Year:2016 | Volume:27 | Issue:8 Page(s): 672-682

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Title

EFFECT OF FULLERENE NANOPARTICLES ON BRAIN INFARCTION AND HISTOPATHOLOGICAL CHANGES DURING TRANSIENT AND FOCAL CEREBRAL ISCHEMIA IN RAT

Author(s)

Aryafar Masiha | MOHAMMADI MOHAMMAD TAGHI | Issue Writer Certificate

Keywords

FULLERENEQ1

OXIDATIVE STRESSQ2

BRAIN INFARCTIONQ1

NEURODEGENERATIONQ1

ISCHEMIC STROKEQ1

Abstract

Background & Aims: According to the recent studies, FULLERENE nanoparticles have a potent scavenging property for free radicals in biological environments. Since reactive oxygen species (ROS) is a fundamental mechanism of brain damage in stroke, we aimed to evaluate the neuroprotective effects of FULLERENE nanoparticles on ischemia-induced brain injuries in experimental model of stroke.Materials & Methods: Experiment was performed in three groups of rats (N=28): Sham, Control ischemia, and Ischemic treatment. Ischemia was induced by 90 min middle cerebral artery occlusion (MCAO) followed by 24 hours reperfusion. Rats received FULLERENE (5 mg/kg, intraperitoneally) 60 min before induction of MCAO. Cortical and striatal infarction (TTC staining), and histopathological alterations were assessed 24 hours after termination of MCAO.Results: MCAO induced BRAIN INFARCTION in cortical (307±16 mm3) and striatal (115±21 mm3) areas concomitant increase the histopathological damages. Administration of FULLERENE significantly reduced the infarction in cortical (166±15 mm3) and striatal (54±7 mm3) areas 45% and 53%, respectively. Also, FULLERENE decreased the mortality rate of ischemic treated rats (33.33%) compared to ischemic nontreated rats (9.09%) in accompany with the reduction of histopathological damages.Conclusion: It is concluded that FULLERENE nanoparticles, as a potent antioxidant factor, effectively reduce ischemia-induced brain damage and prevent NEURODEGENERATION possibly through scavenging property of free radicals.

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APA: Copy

Aryafar, Masiha, & MOHAMMADI, MOHAMMAD TAGHI. (2016). EFFECT OF FULLERENE NANOPARTICLES ON BRAIN INFARCTION AND HISTOPATHOLOGICAL CHANGES DURING TRANSIENT AND FOCAL CEREBRAL ISCHEMIA IN RAT. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 27(8), 672-682. SID. https://sid.ir/paper/64174/en

Vancouver: Copy

Aryafar Masiha, MOHAMMADI MOHAMMAD TAGHI. EFFECT OF FULLERENE NANOPARTICLES ON BRAIN INFARCTION AND HISTOPATHOLOGICAL CHANGES DURING TRANSIENT AND FOCAL CEREBRAL ISCHEMIA IN RAT. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2016;27(8):672-682. Available from: https://sid.ir/paper/64174/en

IEEE: Copy

Masiha Aryafar, and MOHAMMAD TAGHI MOHAMMADI, “EFFECT OF FULLERENE NANOPARTICLES ON BRAIN INFARCTION AND HISTOPATHOLOGICAL CHANGES DURING TRANSIENT AND FOCAL CEREBRAL ISCHEMIA IN RAT,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 27, no. 8, pp. 672–682, 2016, [Online]. Available: https://sid.ir/paper/64174/en

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