THE 4G/5G GENETIC VARIATION IN THE PROMOTER OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN PATIENTS WITH RECURRENT MISCARRIAGE AND HEALTHY CONTROLS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BAGHERI MORTAZA; ABDI RAD ISA; OMRANI MIRDAVOUD; NANBAKHSH FARIBA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Studies in Medical Sciences Year:2011 | Volume:22 | Issue:2 Page(s): 85-91

Download Full-Text

Persian Verion

View:

1,049

Download:

Cites:

Information Journal Paper

Title

THE 4G/5G GENETIC VARIATION IN THE PROMOTER OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN PATIENTS WITH RECURRENT MISCARRIAGE AND HEALTHY CONTROLS

Author(s)

BAGHERI MORTAZA | ABDI RAD ISA | OMRANI MIRDAVOUD | NANBAKHSH FARIBA | Issue Writer Certificate

Keywords

PROMOTER OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENEQ2

RECURRENT MISCARRIAGEQ2

GENETIC VARIATIONQ2

4GQ2

5GQ2

Abstract

Background & Aims: Deletion/insertion of a single guanosine in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene, resulting in two alleles containing either 4 or 5 guanosines (G). Results of recent studies showed that presence of PAI-1 4G allele may increase the risk of human disease. The aim of present study was to determine the 4G/5G GENETIC VARIATION in the promoter of PAI-1 gene in patients with RECURRENT MISCARRIAGE and healthy controls.Materials and Methods: Genotypes of 45 cases with RECURRENT MISCARRIAGE (at least 3 unexplained abortions) and 64 controls were determined by RFLP-PCR.Results: The findings of present study shows: Frequency (percent) of PAI-1 4G allele in cases and controls were 29 (32.22%) and47 (36.72%), respectively; frequency (percent) of PAI-1 5G allele in cases and controls were 61 (67.78%) and 81 (63.28%), respectively. Frequency (percent) of PAI-1 5G/5G and 4G/4G was 16 (35.56%) and 29 (64.44%) in cases and 17 (26.56%) and 47 (73.44%) in controls, respectively. PAI-1 4G/4G genotype was not observed in studied groups. Statistical analysis showed that the frequencies of PAI-1 -675 4G/5G alleles and genotypes did not significantly differ between cases and controls.Conclusion: The findings of present study show that it is not possible to find any association between PAI-1 -675 4G allele and predisposition to RECURRENT MISCARRIAGE in tested population.

Cites

No record.

References

No record.

Cite

APA: Copy

BAGHERI, MORTAZA, ABDI RAD, ISA, OMRANI, MIRDAVOUD, & NANBAKHSH, FARIBA. (2011). THE 4G/5G GENETIC VARIATION IN THE PROMOTER OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN PATIENTS WITH RECURRENT MISCARRIAGE AND HEALTHY CONTROLS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 22(2), 85-91. SID. https://sid.ir/paper/64291/en

Vancouver: Copy

BAGHERI MORTAZA, ABDI RAD ISA, OMRANI MIRDAVOUD, NANBAKHSH FARIBA. THE 4G/5G GENETIC VARIATION IN THE PROMOTER OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN PATIENTS WITH RECURRENT MISCARRIAGE AND HEALTHY CONTROLS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2011;22(2):85-91. Available from: https://sid.ir/paper/64291/en

IEEE: Copy

MORTAZA BAGHERI, ISA ABDI RAD, MIRDAVOUD OMRANI, and FARIBA NANBAKHSH, “THE 4G/5G GENETIC VARIATION IN THE PROMOTER OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN PATIENTS WITH RECURRENT MISCARRIAGE AND HEALTHY CONTROLS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 22, no. 2, pp. 85–91, 2011, [Online]. Available: https://sid.ir/paper/64291/en

Related Journal Papers